SHORT-TERM TOXICITY STUDY IN RATS DOSED WITH PEPPERMINT OIL

Publication: Research - peer-reviewJournal article – Annual report year: 1983

  • Author: Thorup, I.

    Technical University of Denmark, National Food Institute

  • Author: Würtzen, G.

    Technical University of Denmark, National Food Institute

  • Author: Carstensen, J.

    Technical University of Denmark, National Food Institute

  • Author: Olsen, P.

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Pulegone and menthol, components of peppermint oil, were investigated in rats. The substances were administered by gavage for 28 days at 0, 20, 80, 160 mg pulegone and 0, 200, 400, 800 mg menthol/kg body wt./day, respectively. At the two highest doses, pulegone induced atonia, decreased blood creatinine content, lowered terminal body weight and caused histopathological changes in the liver and in the white matter of cerebellum. For menthol at all dose levels a significant increase in absolute and relative liver weights and vacuolisation of hepatocytes was found. No sign of encephalopathy was observed in rats given menthol.
Original languageEnglish
JournalToxicology Letters
Publication date1983
Volume19
Journal number3
Pages211-215
ISSN0378-4274
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 19
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