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Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study. / Kupers, Ron; Frokjaer, Vibe G.; Erritzoe, David; Naert, Arne; Budtz-Joergensen, Esben; Nielsen, Finn Årup; Kehlet, Henrik; Knudsen, Gitte Moos.

In: NeuroImage, Vol. 54, No. 2, 2010, p. 1336-1343.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Harvard

Kupers, R, Frokjaer, VG, Erritzoe, D, Naert, A, Budtz-Joergensen, E, Nielsen, FÅ, Kehlet, H & Knudsen, GM 2010, 'Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study' NeuroImage, vol 54, no. 2, pp. 1336-1343., 10.1016/j.neuroimage.2010.09.010

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Kupers, Ron; Frokjaer, Vibe G.; Erritzoe, David; Naert, Arne; Budtz-Joergensen, Esben; Nielsen, Finn Årup; Kehlet, Henrik; Knudsen, Gitte Moos / Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study.

In: NeuroImage, Vol. 54, No. 2, 2010, p. 1336-1343.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{57a55279977249759013bdc6c79e7ef6,
title = "Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study",
keywords = "Neuroimaginge",
publisher = "Academic Press",
author = "Ron Kupers and Frokjaer, {Vibe G.} and David Erritzoe and Arne Naert and Esben Budtz-Joergensen and Nielsen, {Finn Årup} and Henrik Kehlet and Knudsen, {Gitte Moos}",
year = "2010",
doi = "10.1016/j.neuroimage.2010.09.010",
volume = "54",
number = "2",
pages = "1336--1343",
journal = "NeuroImage",
issn = "1053-8119",

}

RIS

TY - JOUR

T1 - Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study

A1 - Kupers,Ron

A1 - Frokjaer,Vibe G.

A1 - Erritzoe,David

A1 - Naert,Arne

A1 - Budtz-Joergensen,Esben

A1 - Nielsen,Finn Årup

A1 - Kehlet,Henrik

A1 - Knudsen,Gitte Moos

AU - Kupers,Ron

AU - Frokjaer,Vibe G.

AU - Erritzoe,David

AU - Naert,Arne

AU - Budtz-Joergensen,Esben

AU - Nielsen,Finn Årup

AU - Kehlet,Henrik

AU - Knudsen,Gitte Moos

PB - Academic Press

PY - 2010

Y1 - 2010

N2 - There is a large body of evidence that the serotonergic system plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) with the serotonin transporter (SERT) tracer [11C]DASB to study the relationship between SERT binding in the brain and responses to noxious heat stimulation in a group of 21 young healthy volunteers. Responses to noxious heat stimuli were assessed in a separate psychophysical experiment and included measurements of pain threshold, pain tolerance, and responses to phasic noxious heat stimuli and to a long lasting (7-minute) tonic noxious heat stimulus. PET data were analyzed using both volume-of-interest (VOI) and voxel-based approaches. VOI analysis revealed a significant negative correlation between tonic pain ratings and SERT binding in the hypothalamus (r = −0.59; p = 0.008), a finding confirmed by the parametric analysis. The parametric analysis also revealed a negative correlation between tonic pain ratings and SERT binding in the right anterior insula. Measures of regional SERT binding did not correlate with pain threshold or with responses to short phasic suprathreshold phasic heat stimuli. Finally, the VOI analysis revealed a positive correlation between pain tolerance and SERT binding in the hypothalamus (r = 0.53; p = 0.02) although this was not seen in the parametric analysis. These data extend our earlier observation that cortical 5-HT receptors co-determine responses to tonic but not to phasic pain. The negative correlation between SERT binding in the hypothalamus and insula with tonic pain ratings suggests a possible serotonergic control of the role of these areas in the modulation or in the affective appreciation of pain.

AB - There is a large body of evidence that the serotonergic system plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) with the serotonin transporter (SERT) tracer [11C]DASB to study the relationship between SERT binding in the brain and responses to noxious heat stimulation in a group of 21 young healthy volunteers. Responses to noxious heat stimuli were assessed in a separate psychophysical experiment and included measurements of pain threshold, pain tolerance, and responses to phasic noxious heat stimuli and to a long lasting (7-minute) tonic noxious heat stimulus. PET data were analyzed using both volume-of-interest (VOI) and voxel-based approaches. VOI analysis revealed a significant negative correlation between tonic pain ratings and SERT binding in the hypothalamus (r = −0.59; p = 0.008), a finding confirmed by the parametric analysis. The parametric analysis also revealed a negative correlation between tonic pain ratings and SERT binding in the right anterior insula. Measures of regional SERT binding did not correlate with pain threshold or with responses to short phasic suprathreshold phasic heat stimuli. Finally, the VOI analysis revealed a positive correlation between pain tolerance and SERT binding in the hypothalamus (r = 0.53; p = 0.02) although this was not seen in the parametric analysis. These data extend our earlier observation that cortical 5-HT receptors co-determine responses to tonic but not to phasic pain. The negative correlation between SERT binding in the hypothalamus and insula with tonic pain ratings suggests a possible serotonergic control of the role of these areas in the modulation or in the affective appreciation of pain.

KW - Neuroimaginge

U2 - 10.1016/j.neuroimage.2010.09.010

DO - 10.1016/j.neuroimage.2010.09.010

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 2

VL - 54

SP - 1336

EP - 1343

ER -