Self-assembled diphenylalanine nanowires for cellular studies and sensor applications.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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@article{a697229ae6034cb1b222d8374baa14bd,
title = "Self-assembled diphenylalanine nanowires for cellular studies and sensor applications.",
publisher = "American Scientific Publishers",
author = "Luigi Sasso and Indumathi Vedarethinam and Jenny Emnéus and Svendsen, {Winnie Edith} and Jaime Castillo",
year = "2012",
doi = "10.1166/jnn.2012.4534",
volume = "12",
pages = "3077--3083",
journal = "Journal of Nanoscience and Nanotechnology",
issn = "1533-4880",

}

RIS

TY - JOUR

T1 - Self-assembled diphenylalanine nanowires for cellular studies and sensor applications.

A1 - Sasso,Luigi

A1 - Vedarethinam,Indumathi

A1 - Emnéus,Jenny

A1 - Svendsen,Winnie Edith

A1 - Castillo,Jaime

AU - Sasso,Luigi

AU - Vedarethinam,Indumathi

AU - Emnéus,Jenny

AU - Svendsen,Winnie Edith

AU - Castillo,Jaime

PB - American Scientific Publishers

PY - 2012

Y1 - 2012

N2 - In this paper we present a series of experiments showing that vertical self-assembled diphenylalanine peptide nanowires (PNWs) are a suitable candidate material for cellular biosensing. We grew HeLa and PC12 cells onto PNW modified gold surfaces and observed no hindrance of cell growth caused by the peptide nanostructures; furthermore we studied the properties of PNWs by investigating their influence on the electrochemical behavior of gold electrodes. The PNWs were functionalized with polypyrrole (PPy) by chemical polymerization, therefore creating conducting peptide/polymer nanowire structures vertically attached to a metal electrode. The electroactivity of such structures was characterized by cyclic voltammetry. The PNW/PPy modified electrodes were finally used as amperometric dopamine sensors, yielding a detection limit of 3,1 µM.

AB - In this paper we present a series of experiments showing that vertical self-assembled diphenylalanine peptide nanowires (PNWs) are a suitable candidate material for cellular biosensing. We grew HeLa and PC12 cells onto PNW modified gold surfaces and observed no hindrance of cell growth caused by the peptide nanostructures; furthermore we studied the properties of PNWs by investigating their influence on the electrochemical behavior of gold electrodes. The PNWs were functionalized with polypyrrole (PPy) by chemical polymerization, therefore creating conducting peptide/polymer nanowire structures vertically attached to a metal electrode. The electroactivity of such structures was characterized by cyclic voltammetry. The PNW/PPy modified electrodes were finally used as amperometric dopamine sensors, yielding a detection limit of 3,1 µM.

U2 - 10.1166/jnn.2012.4534

DO - 10.1166/jnn.2012.4534

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

SN - 1533-4880

VL - 12

SP - 3077

EP - 3083

ER -