Screening of Aspergillus nidulans metabolites from habitat mimicking media using LC-DAD-TOFMS system

Publication: Research - peer-reviewConference abstract in journal – Annual report year: 2012

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Fungi are a valuable source of metabolites and other bioactive compounds. These compounds are essential for human society, and it is estimated that around 49% of the drugs used to treat cancer are natural products or derived therefrom. Six different wild types of Aspergillus nidulans have been cultured on a range of different habitat mimicking media. Extracts from the fungi were analyzed using a LC-DAD-TOFMS system, and by screening the extracts using an in-house database of known fungal metabolites. Using this database we were able to easily select unknown compounds, and dereplicate these using the spectrometric and spectroscopic data obtained from the analysis. The Analysis revealed several metabolites not previously reported in A. nidulans as well as a novel metabolite.
Original languageEnglish
JournalPlanta Medica
Publication date2012
Volume78
IssueP167
ISSN0032-0943
DOIs
StatePublished

Conference

ConferenceInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health
CountryUnited States
CityNew York City, NY
Period28/07/1201/08/12
CitationsWeb of Science® Times Cited: No match on DOI
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