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DOI

  • Author: Schulte, Rolf F.

    GE Global Research

  • Author: Sperl, Jonathan I.

    GE Global Research

  • Author: Weidl, Eliane

    Technische Universität München

  • Author: Menzel, Marion I.

    GE Global Research

  • Author: Janich, Martin A.

    GE Global Research

  • Author: Khegai, Oleksandr

    GE Global Research

  • Author: Durst, Markus

    GE Global Research

  • Author: Ardenkjær-Larsen, Jan Henrik

    Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Glaser, Steffen J.

    Technische Universität München

  • Author: Haase, Axel

    Technische Universität München

  • Author: Schwaiger, Markus

    Technische Universität München

  • Author: Wiesinger, Florian

    GE Global Research

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Within the last decade hyperpolarized [1‐13C] pyruvate chemical‐shift imaging has demonstrated impressive potential for metabolic MR imaging for a wide range of applications in oncology, cardiology, and neurology. In this work, a highly efficient pulse sequence is described for time‐resolved, multislice chemical shift imaging of the injected substrate and obtained downstream metabolites. Using spectral‐spatial excitation in combination with single‐shot spiral data acquisition, the overall encoding is evenly distributed between excitation and signal reception, allowing the encoding of one full two‐dimensional metabolite image per excitation. The signal‐to‐noise ratio can be flexibly adjusted and optimized using lower flip angles for the pyruvate substrate and larger ones for the downstream metabolites. Selectively adjusting the excitation of the down‐stream metabolites to 90° leads to a so‐called “saturation‐recovery” scheme with the detected signal content being determined by forward conversion of the available pyruvate. In case of repetitive excitations, the polarization is preserved using smaller flip angles for pyruvate. Metabolic exchange rates are determined spatially resolved from the metabolite images using a simplified two‐site exchange model. This novel contrast is an important step toward more quantitative metabolic imaging. Goal of this work was to derive, analyze, and implement this “saturation‐recovery metabolic exchange rate imaging” and demonstrate its capabilities in four rats bearing subcutaneous tumors. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Publication date2013
Volume69
Issue5
Pages1209-1216
ISSN0740-3194
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 5

Keywords

  • Metabolic imaging, Hyperpolarization, [1-13C]pyruvate, Saturation-recovery, Metabolic exchange rate, Magnetic resonance spectroscopy, Spectral-spatial excitation
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