TY - JOUR

T1 - Roll-to-roll fabricated lab-on-a-chip devices

A1 - Vig,Asger Laurberg

A1 - Mäkelä,Tapio

A1 - Majander,Päivi

A1 - Lambertini,Vito

A1 - Ahopelto,Jouni

A1 - Kristensen,Anders

AU - Vig,Asger Laurberg

AU - Mäkelä,Tapio

AU - Majander,Päivi

AU - Lambertini,Vito

AU - Ahopelto,Jouni

AU - Kristensen,Anders

PY - 2011

Y1 - 2011

N2 - <p>We present a high-volume fabrication technique for making polymer lab-on-a-chip devices. Microfluidic separation devices, relying on pinched flow fraction, are roll-to-roll fabricated in a cellulose acetate (CA) film at a volume of 360 devices h−1 for a cost of approximately 0.5 euro/device. The manufacturing process consists of two steps: (i) roll-to-roll thermal nanoimprint for patterning the microchannels into a CA film and (ii) roll-to-roll lamination for bonding another CA film onto the imprinted film to seal the microchannels. Reverse gravure coating is used to apply an adhesive polymer onto the CA lid film before roll-to-roll lamination in order to increase the bonding strength. The fabricated devices are compared with planar imprinted devices with regard to the cross-sectional profile of the imprinted channels and their separation functionality. The separation functionality is characterized using fluorescent polystyrene microspheres with diameters ranging from 0.5 to 5 µm.</p>

AB - <p>We present a high-volume fabrication technique for making polymer lab-on-a-chip devices. Microfluidic separation devices, relying on pinched flow fraction, are roll-to-roll fabricated in a cellulose acetate (CA) film at a volume of 360 devices h−1 for a cost of approximately 0.5 euro/device. The manufacturing process consists of two steps: (i) roll-to-roll thermal nanoimprint for patterning the microchannels into a CA film and (ii) roll-to-roll lamination for bonding another CA film onto the imprinted film to seal the microchannels. Reverse gravure coating is used to apply an adhesive polymer onto the CA lid film before roll-to-roll lamination in order to increase the bonding strength. The fabricated devices are compared with planar imprinted devices with regard to the cross-sectional profile of the imprinted channels and their separation functionality. The separation functionality is characterized using fluorescent polystyrene microspheres with diameters ranging from 0.5 to 5 µm.</p>

KW - Nanolithography

KW - Nanoscale pattern formation

KW - Flows in micro-electromechanical systems (MEMS) and nano-electromechanical systems (NEMS)

KW - Fluidics

KW - Biophysical techniques

U2 - 10.1088/0960-1317/21/3/035006

DO - 10.1088/0960-1317/21/3/035006

JO - Journal of Micromechanics and Microengineering

JF - Journal of Micromechanics and Microengineering

SN - 09601317

IS - 3

VL - 21

SP - 035006

ER -