Residential radon and lung cancer incidence in a Danish cohort

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Residential radon and lung cancer incidence in a Danish cohort. / Bräuner, Elvira Vaclavik; Andersen, Claus Erik; Sørensen, Mette; Jovanovic Andersen, Zorana; Gravesen, Peter; Ulbak, Kaare; Hertel, Ole; Pedersen, Camilla; Overvad, Kim; Tjønneland, Anne; Raaschou-Nielsen, Ole Lundsgaard.

In: Environmental Research, Vol. 118, 2012, p. 130-136.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Bräuner, EV, Andersen, CE, Sørensen, M, Jovanovic Andersen, Z, Gravesen, P, Ulbak, K, Hertel, O, Pedersen, C, Overvad, K, Tjønneland, A & Raaschou-Nielsen, OL 2012, 'Residential radon and lung cancer incidence in a Danish cohort' Environmental Research, vol 118, pp. 130-136., 10.1016/j.envres.2012.05.012

APA

Bräuner, E. V., Andersen, C. E., Sørensen, M., Jovanovic Andersen, Z., Gravesen, P., Ulbak, K., Hertel, O., Pedersen, C., Overvad, K., Tjønneland, A., & Raaschou-Nielsen, O. L. (2012). Residential radon and lung cancer incidence in a Danish cohort. Environmental Research, 118, 130-136. 10.1016/j.envres.2012.05.012

CBE

Bräuner EV, Andersen CE, Sørensen M, Jovanovic Andersen Z, Gravesen P, Ulbak K, Hertel O, Pedersen C, Overvad K, Tjønneland A, Raaschou-Nielsen OL. 2012. Residential radon and lung cancer incidence in a Danish cohort. Environmental Research. 118:130-136. Available from: 10.1016/j.envres.2012.05.012

MLA

Vancouver

Bräuner EV, Andersen CE, Sørensen M, Jovanovic Andersen Z, Gravesen P, Ulbak K et al. Residential radon and lung cancer incidence in a Danish cohort. Environmental Research. 2012;118:130-136. Available from: 10.1016/j.envres.2012.05.012

Author

Bräuner, Elvira Vaclavik; Andersen, Claus Erik; Sørensen, Mette; Jovanovic Andersen, Zorana; Gravesen, Peter; Ulbak, Kaare; Hertel, Ole; Pedersen, Camilla; Overvad, Kim; Tjønneland, Anne; Raaschou-Nielsen, Ole Lundsgaard / Residential radon and lung cancer incidence in a Danish cohort.

In: Environmental Research, Vol. 118, 2012, p. 130-136.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{8296e46d141941a6a99b7017ff910211,
title = "Residential radon and lung cancer incidence in a Danish cohort",
publisher = "Academic Press",
author = "Bräuner, {Elvira Vaclavik} and Andersen, {Claus Erik} and Mette Sørensen and {Jovanovic Andersen}, Zorana and Peter Gravesen and Kaare Ulbak and Ole Hertel and Camilla Pedersen and Kim Overvad and Anne Tjønneland and Raaschou-Nielsen, {Ole Lundsgaard}",
year = "2012",
doi = "10.1016/j.envres.2012.05.012",
volume = "118",
pages = "130--136",
journal = "Environmental Research",
issn = "0013-9351",

}

RIS

TY - JOUR

T1 - Residential radon and lung cancer incidence in a Danish cohort

A1 - Bräuner,Elvira Vaclavik

A1 - Andersen,Claus Erik

A1 - Sørensen,Mette

A1 - Jovanovic Andersen,Zorana

A1 - Gravesen,Peter

A1 - Ulbak,Kaare

A1 - Hertel,Ole

A1 - Pedersen,Camilla

A1 - Overvad,Kim

A1 - Tjønneland,Anne

A1 - Raaschou-Nielsen,Ole Lundsgaard

AU - Bräuner,Elvira Vaclavik

AU - Andersen,Claus Erik

AU - Sørensen,Mette

AU - Jovanovic Andersen,Zorana

AU - Gravesen,Peter

AU - Ulbak,Kaare

AU - Hertel,Ole

AU - Pedersen,Camilla

AU - Overvad,Kim

AU - Tjønneland,Anne

AU - Raaschou-Nielsen,Ole Lundsgaard

PB - Academic Press

PY - 2012

Y1 - 2012

N2 - High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993–1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed.Median estimated radon was 35.8Bq/m3. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69–1.56) in association with a 100Bq/m3 higher radon concentration and 1.67 (95% CI: 0.69–4.04) among non-smokers. We found no evidence of effect modification.We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

AB - High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993–1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed.Median estimated radon was 35.8Bq/m3. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69–1.56) in association with a 100Bq/m3 higher radon concentration and 1.67 (95% CI: 0.69–4.04) among non-smokers. We found no evidence of effect modification.We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

KW - Residential radon

KW - Lung cancer

KW - Prospective cohort

KW - Prediction

KW - Register based study

U2 - 10.1016/j.envres.2012.05.012

DO - 10.1016/j.envres.2012.05.012

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

VL - 118

SP - 130

EP - 136

ER -