Publication: Research - peer-review › Journal article – Annual report year: 2009
A method for the formation of synthetic macrocycles with different ring sizes from diols is presented. Reacting a simple diol precursor with electrophilic reagents leads to a cyclic carbonate, sulfite or phosphate in a single step in 25-60% yield. Converting the cyclization precursor to a bis-electrophilic iodide or aldehyde enables preparation of a cyclic sulfide and amine, respectively, the latter using a double reductive amination to induce ring closure.
|Citations||Web of Science® Times Cited: 3|
- Macrocyclization, Reductive amination, Cyclic esters