Standard

Qualitative and quantitative analyses of the morphological-dynamics of early cardiac pump action using video densidometry and optical coherence tomography (OCT). / Männer, Jörg; Thrane, Lars; Thommes, Jan; Happel, Christoph M.; Yelbuz, Mesud.

Weinstein 2010 Abstract Book. 2010.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2010

Harvard

APA

CBE

MLA

Vancouver

Author

Männer, Jörg; Thrane, Lars; Thommes, Jan; Happel, Christoph M.; Yelbuz, Mesud / Qualitative and quantitative analyses of the morphological-dynamics of early cardiac pump action using video densidometry and optical coherence tomography (OCT).

Weinstein 2010 Abstract Book. 2010.

Publication: Research - peer-reviewConference abstract in proceedings – Annual report year: 2010

Bibtex

@inbook{0ed8ab7d6ed14a15a752b64c9deb48c9,
title = "Qualitative and quantitative analyses of the morphological-dynamics of early cardiac pump action using video densidometry and optical coherence tomography (OCT)",
author = "Jörg Männer and Lars Thrane and Jan Thommes and Happel, {Christoph M.} and Mesud Yelbuz",
year = "2010",
booktitle = "Weinstein 2010 Abstract Book",

}

RIS

TY - ABST

T1 - Qualitative and quantitative analyses of the morphological-dynamics of early cardiac pump action using video densidometry and optical coherence tomography (OCT)

A1 - Männer,Jörg

A1 - Thrane,Lars

A1 - Thommes,Jan

A1 - Happel,Christoph M.

A1 - Yelbuz,Mesud

AU - Männer,Jörg

AU - Thrane,Lars

AU - Thommes,Jan

AU - Happel,Christoph M.

AU - Yelbuz,Mesud

PY - 2010

Y1 - 2010

N2 - During the initial phase of its pump action, vertebrate embryonic hearts are seen as valveless tubular pumps. It was traditionally thought that these tubular hearts generate unidirectional blood flow via peristalsis. Recently, however, the pumping mechanism of early embryonic hearts has become a matter of dispute. Uncovering of the pumping mechanism of tubular embryonic hearts requires detailed information about the hemodynamics as well as morphological dynamics of their pump action. We have therefore analyzed the morphological dynamics of cardiac pump action in chick embryos (HH-stages 16-18) in shelless culture using densidometric analyses of high-speed video recordings and by M-mode optical coherence tomography (OCT). The high-speed video camera and the OCT probe were integrated into an environmental chamber, which provided stable physiological conditions during examination of the embryos. We have recorded striking differences in the contraction behavior (e.g. contraction speed, duration of systolic occlusion of heart lumen) of the embryonic heart segments (common atrium, AV-canal, embryonic ventricles, outflow tract). Moreover, we show, for the first time, the pump action of tubular embryonic chick hearts in frontal views, which provide a much better understanding of early cardiac pump action than the traditional right or left lateral views.

AB - During the initial phase of its pump action, vertebrate embryonic hearts are seen as valveless tubular pumps. It was traditionally thought that these tubular hearts generate unidirectional blood flow via peristalsis. Recently, however, the pumping mechanism of early embryonic hearts has become a matter of dispute. Uncovering of the pumping mechanism of tubular embryonic hearts requires detailed information about the hemodynamics as well as morphological dynamics of their pump action. We have therefore analyzed the morphological dynamics of cardiac pump action in chick embryos (HH-stages 16-18) in shelless culture using densidometric analyses of high-speed video recordings and by M-mode optical coherence tomography (OCT). The high-speed video camera and the OCT probe were integrated into an environmental chamber, which provided stable physiological conditions during examination of the embryos. We have recorded striking differences in the contraction behavior (e.g. contraction speed, duration of systolic occlusion of heart lumen) of the embryonic heart segments (common atrium, AV-canal, embryonic ventricles, outflow tract). Moreover, we show, for the first time, the pump action of tubular embryonic chick hearts in frontal views, which provide a much better understanding of early cardiac pump action than the traditional right or left lateral views.

UR - http://weinstein.heartrepair.eu/

BT - Weinstein 2010 Abstract Book

T2 - Weinstein 2010 Abstract Book

ER -