• Author: Männer, Jörg

    Department of Anatomy and Embryology, Georg-August-University of Göttingen, Germany

  • Author: Thrane, Lars

    Terahertz Technologies and Biophotonics, Department of Photonics Engineering, Technical University of Denmark, Frederiksborgvej 399 , 4000, Roskilde, Denmark

  • Author: Thommes, Jan

    Institute of Mechatronic Systems, Leibniz University Hannover, Germany

  • Author: Happel, Christoph M.

    Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Germany

  • Author: Yelbuz, Mesud

    Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Germany

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During the initial phase of its pump action, vertebrate embryonic hearts are seen as valveless tubular pumps. It was traditionally thought that these tubular hearts generate unidirectional blood flow via peristalsis. Recently, however, the pumping mechanism of early embryonic hearts has become a matter of dispute. Uncovering of the pumping mechanism of tubular embryonic hearts requires detailed information about the hemodynamics as well as morphological dynamics of their pump action. We have therefore analyzed the morphological dynamics of cardiac pump action in chick embryos (HH-stages 16-18) in shelless culture using densidometric analyses of high-speed video recordings and by M-mode optical coherence tomography (OCT). The high-speed video camera and the OCT probe were integrated into an environmental chamber, which provided stable physiological conditions during examination of the embryos. We have recorded striking differences in the contraction behavior (e.g. contraction speed, duration of systolic occlusion of heart lumen) of the embryonic heart segments (common atrium, AV-canal, embryonic ventricles, outflow tract). Moreover, we show, for the first time, the pump action of tubular embryonic chick hearts in frontal views, which provide a much better understanding of early cardiac pump action than the traditional right or left lateral views.
Original languageEnglish
Title of host publicationWeinstein 2010 Abstract Book
Number of pages232
Publication date2010
StatePublished

Conference

ConferenceWeinstein 2010 : Cardiovascular Development Conference
CityAmsterdam, The Netherlands
Period01/01/10 → …

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