Profiling of Substrates for Zinc‐dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro

Publication: Research - peer-reviewJournal article – Annual report year: 2012

View graph of relations

Systematic screening of the activities of the eleven human zinc-dependent lysine deacylases against a series of fluorogenic substrates (see scheme) as well as kinetic evaluation revealed substrates for screenings of histone deacetylases HDAC10 and HDAC11 at reasonably low enzyme concentrations. Furthermore, HDAC3 in complex with nuclear receptor corepressor 1 (HDAC3–NCoR1) was shown to harbor decrotonylase activity in vitro.
Original languageEnglish
JournalAngewandte Chemie (International Edition)
Publication date2012
Volume51
Issue36
Pages9083-9087
ISSN1433-7851
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 9

Keywords

  • Enzymes, Epigenetics, Histone deacetylases, Inhibitors, Posttranslational modifications
Download as:
Download as PDF
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
Word

ID: 12143461