Process technology for multi-enzymatic reaction systems

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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In recent years, biocatalysis has started to provide an important green tool in synthetic organic chemistry. Currently, the idea of using multi-enzymatic systems for industrial production of chemical compounds becomes increasingly attractive. Recent examples demonstrate the potential of enzymatic synthesis and fermentation as an alternative to chemical-catalysis for the production of pharmaceuticals and fine chemicals. In particular, the use of multiple enzymes is of special interest. However, many challenges remain in the scale-up of a multi-enzymatic system. This review summarizes and discusses the technology options and strategies that are available for the development of multi-enzymatic processes. Some engineering tools, including kinetic models and operating windows, for developing and evaluating such processes are also introduced.
Original languageEnglish
JournalBioresource Technology
Publication date2012
Volume115
Pages183-195
ISSN0960-8524
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 16

Keywords

  • Biocatalysis, Multi-enzymatic synthesis, Process technology, Reactor selection
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