Process for the Manufacture of Ajoene Derivatives

Publication: ResearchPatent – Annual report year: 2012

Standard

Process for the Manufacture of Ajoene Derivatives. / Larsen, Thomas Ostenfeld (Inventor); Givskov, Michael Christian (Inventor); Bjarnsholt, Thomas (Inventor); Jakobsen, Tim Holm (Inventor); Christensen, Louise Dahl (Inventor); Shanmugham, Meenakshi Sundaram (Inventor); Phipps, Richard Kerry (Inventor); Tanner, David Ackland (Inventor); Høiby, Niels (Inventor); Jensen, Peter Østrup (Inventor).

IPC No.: A61K31/105. Patent No.: WO2012076016. Jun 14, 2012.

Publication: ResearchPatent – Annual report year: 2012

Harvard

Larsen, TO, Givskov, MC, Bjarnsholt, T, Jakobsen, TH, Christensen, LD, Shanmugham, MS, Phipps, RK, Tanner, DA, Høiby, N & Jensen, PØ Jun. 14 2012, Process for the Manufacture of Ajoene Derivatives, Patent No. WO2012076016, IPC No. A61K31/105.

APA

Larsen, T. O., Givskov, M. C., Bjarnsholt, T., Jakobsen, T. H., Christensen, L. D., Shanmugham, M. S., ... Jensen, P. Ø. (2012). IPC No. A61K31/105. Process for the Manufacture of Ajoene Derivatives (Patent No. WO2012076016.)

CBE

Larsen TO, Givskov MC, Bjarnsholt T, Jakobsen TH, Christensen LD, Shanmugham MS, Phipps RK, Tanner DA, Høiby N, Jensen PØ, inventors. 14-Jun-2012. Process for the Manufacture of Ajoene Derivatives. IPC No. A61K31/105. Patent No. WO2012076016.

MLA

Larsen, Thomas Ostenfeld et al.. 2012. IPC No. A61K31/105. Patent No. WO2012076016.

Vancouver

Larsen TO, Givskov MC, Bjarnsholt T, Jakobsen TH, Christensen LD, Shanmugham MS et al, inventors. Process for the Manufacture of Ajoene Derivatives. IPC No. A61K31/105. Patent No. WO2012076016. Jun 14, 2012.

Author

Larsen, Thomas Ostenfeld (Inventor); Givskov, Michael Christian (Inventor); Bjarnsholt, Thomas (Inventor); Jakobsen, Tim Holm (Inventor); Christensen, Louise Dahl (Inventor); Shanmugham, Meenakshi Sundaram (Inventor); Phipps, Richard Kerry (Inventor); Tanner, David Ackland (Inventor); Høiby, Niels (Inventor); Jensen, Peter Østrup (Inventor) / Process for the Manufacture of Ajoene Derivatives.

IPC No.: A61K31/105. Patent No.: WO2012076016. Jun 14, 2012.

Publication: ResearchPatent – Annual report year: 2012

Bibtex

@misc{62dde783b8ee4457b3f092870215a5af,
title = "Process for the Manufacture of Ajoene Derivatives",
abstract = "The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.",
author = "Larsen, {Thomas Ostenfeld} and Givskov, {Michael Christian} and Thomas Bjarnsholt and Jakobsen, {Tim Holm} and Christensen, {Louise Dahl} and Shanmugham, {Meenakshi Sundaram} and Phipps, {Richard Kerry} and Tanner, {David Ackland} and Niels Høiby and Jensen, {Peter Østrup}",
note = "DTU reference nummer: 92352-08; WO2012076016; A61K31/105",
year = "2012",
type = "Patent",

}

RIS

TY - PAT

T1 - Process for the Manufacture of Ajoene Derivatives

AU - Larsen,Thomas Ostenfeld

AU - Givskov,Michael Christian

AU - Bjarnsholt,Thomas

AU - Jakobsen,Tim Holm

AU - Christensen,Louise Dahl

AU - Shanmugham,Meenakshi Sundaram

AU - Phipps,Richard Kerry

AU - Tanner,David Ackland

AU - Høiby,Niels

AU - Jensen,Peter Østrup

N1 - DTU reference nummer: 92352-08

PY - 2012

Y1 - 2012

N2 - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

AB - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

M3 - Patent

M1 - WO2012076016

Y2 - 2012/06/14

ER -