Process for the Manufacture of Ajoene Derivatives

Publication: Research › Patent – Annual report year: 2012

Standard

Process for the Manufacture of Ajoene Derivatives. / Larsen, Thomas Ostenfeld (Inventor); Givskov, Michael Christian (Inventor); Bjarnsholt, Thomas (Inventor); Jakobsen, Tim Holm (Inventor); Christensen, Louise Dahl (Inventor); Shanmugham, Meenakshi Sundaram (Inventor); Phipps, Richard Kerry (Inventor); Tanner, David Ackland (Inventor); Høiby, Niels (Inventor); Jensen, Peter Østrup (Inventor).

IPC No.: A61K31/105. Jun 14, 2012.

Publication: Research › Patent – Annual report year: 2012

IPC No.: A61K31/105. Jun 14, 2012.

Publication: Research › Patent – Annual report year: 2012

Bibtex

@misc{62dde783b8ee4457b3f092870215a5af,

title = "Process for the Manufacture of Ajoene Derivatives",

author = "Larsen, {Thomas Ostenfeld} and Givskov, {Michael Christian} and Thomas Bjarnsholt and Jakobsen, {Tim Holm} and Christensen, {Louise Dahl} and Shanmugham, {Meenakshi Sundaram} and Phipps, {Richard Kerry} and Tanner, {David Ackland} and Niels Høiby and Jensen, {Peter Østrup}",

note = "DTU reference nummer: 92352-08; WO2012076016; A61K31/105",

year = "2012",

type = "Patent",

}

RIS

TY - PAT

T1 - Process for the Manufacture of Ajoene Derivatives

A1 - Larsen,Thomas Ostenfeld

A1 - Givskov,Michael Christian

A1 - Bjarnsholt,Thomas

A1 - Jakobsen,Tim Holm

A1 - Christensen,Louise Dahl

A1 - Shanmugham,Meenakshi Sundaram

A1 - Phipps,Richard Kerry

A1 - Tanner,David Ackland

A1 - Høiby,Niels

A1 - Jensen,Peter Østrup

AU - Larsen,Thomas Ostenfeld

AU - Givskov,Michael Christian

AU - Bjarnsholt,Thomas

AU - Jakobsen,Tim Holm

AU - Christensen,Louise Dahl

AU - Shanmugham,Meenakshi Sundaram

AU - Phipps,Richard Kerry

AU - Tanner,David Ackland

AU - Høiby,Niels

AU - Jensen,Peter Østrup

PY - 2012

Y1 - 2012

N2 - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

AB - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

M1 - WO2012076016

Y2 - 2012/06/14

ER -