Process considerations for the scale-up and implementation of biocatalysis
Publication: Research - peer-review › Journal article – Annual report year: 2010
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Process considerations for the scale-up and implementation of biocatalysis. / Tufvesson, Pär; Fu, Wenjing; Jensen, Jacob Skibsted; Woodley, John.
In: Food and Bioproducts Processing, Vol. 88, No. C1, 2010, p. 3-11.Publication: Research - peer-review › Journal article – Annual report year: 2010
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TY - JOUR
T1 - Process considerations for the scale-up and implementation of biocatalysis
A1 - Tufvesson,Pär
A1 - Fu,Wenjing
A1 - Jensen,Jacob Skibsted
A1 - Woodley,John
AU - Tufvesson,Pär
AU - Fu,Wenjing
AU - Jensen,Jacob Skibsted
AU - Woodley,John
PB - Elsevier Ltd.
PY - 2010
Y1 - 2010
N2 - With increasing emphasis on renewable feed-stocks and green chemistry, biocatalytic processes will have an important role in the next generation of industrial processes for chemical production. However, in comparison with conventional industrial chemistry, the use of bioprocesses in general and biocatalysis in particular is a rather young technology. Although significant progress has been made in the implementation of new processes (especially in the pharmaceutical industry) no fixed methods for process design have been established to date. In this paper we present some of the considerations required to scale-up a biocatalytic process and some of the recently developed engineering tools available to assist in this procedure. The tools will have a decisive role in helping to identify bottlenecks in the biocatalytic development process and to justify where to put effort and resources.
AB - With increasing emphasis on renewable feed-stocks and green chemistry, biocatalytic processes will have an important role in the next generation of industrial processes for chemical production. However, in comparison with conventional industrial chemistry, the use of bioprocesses in general and biocatalysis in particular is a rather young technology. Although significant progress has been made in the implementation of new processes (especially in the pharmaceutical industry) no fixed methods for process design have been established to date. In this paper we present some of the considerations required to scale-up a biocatalytic process and some of the recently developed engineering tools available to assist in this procedure. The tools will have a decisive role in helping to identify bottlenecks in the biocatalytic development process and to justify where to put effort and resources.
KW - Process design
KW - Reactors
KW - Scale-up
KW - Biocatalysis
U2 - 10.1016/j.fbp.2010.01.003
DO - 10.1016/j.fbp.2010.01.003
JO - Food and Bioproducts Processing
JF - Food and Bioproducts Processing
SN - 0960-3085
IS - C1
VL - 88
SP - 3
EP - 11
ER -