Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children

Research output: Research - peer-reviewJournal article – Annual report year: 2018

DOI

  • Author: Ponce, Marta

    Medical University of Vienna, Austria

  • Author: Schroeder, Fabian

    Austrian Institute of Technology, Austria

  • Author: Bannert, Christina

    Medical University of Vienna, Austria

  • Author: Schmidthaler, Klara

    Medical University of Vienna, Austria

  • Author: Hansen, Christian Skjødt

    Evaxion Biotech, Denmark

  • Author: Bøgh, Katrine Lindholm

    Research Group for Gut Microbiology and Immunology, National Food Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Soldo, Regina

    Austrian Institute of Technology, Austria

  • Author: Tsui, Stephen Kwok-Wing

    Chinese University of Hong Kong, China

  • Author: Weinhäusel, Andreas

    Austrian Institute of Technology, Austria

  • Author: Szépfalusi, Zsolt

    Medical University of Vienna, Austria

  • Author: Eiwegger, Thomas

    University of Toronto, Canada

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The preventive effect of allergen immunotherapy (AIT) on allergy and asthma development is currently assessed using primary and secondary AIT approaches. Knowledge of the immunological effects of these interventions is limited and the impact on epitope diversity remains to be defined. We used high-density peptide arrays that included all known Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) allergens and the whole proteome of Der f to study changes in House Dust Mite (HDM) linear peptide recognition during a 2-year preventive double-blind placebo-controlled sublingual HDM AIT pilot study in 2-5-year-old children with sensitization to HDM but without symptoms. Preventive AIT-treated patients showed significantly higher IgG epitope diversity to HDM allergens compared to placebo-treated individuals at 24 months of treatment (p
Original languageEnglish
JournalAllergy
ISSN0105-4538
DOIs
StateAccepted/In press - 2018
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • AIT, HDM allergy, linear epitopes, peptide array, preventive
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