Pressure-Driven DNA in Nanogroove Arrays: Complex Dynamics Leads to Length- and Topology-Dependent Separation

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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The motion of linear and circular DNA molecules is studied under pressure driven buffer flow in a 50 nm slit channel with arrays of transverse 150 nm deep nanogrooves. Transport occurs through two states of propagation unique to this nanogroove geometry, a slow, stepwise groove-to-groove translation called the “sidewinder” and a fast, continuous tumbling across the grooves called the “tumbleweed”. Dynamical transitions between the two states are observed at fixed buffer velocity. Molecules exhibit size- and topology-dependent velocities.
Original languageEnglish
JournalNano Letters
Publication date2011
ISSN1530-6984
DOIs
StateE-pub ahead of print

Bibliographical note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/nl1044764

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