Predicting Protein Secondary Structure with Markov Models

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2004

Standard

Predicting Protein Secondary Structure with Markov Models. / Fischer, Paul; Larsen, Simon; Thomsen, Claus.

Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005). 2004.

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2004

Harvard

Fischer, P, Larsen, S & Thomsen, C 2004, 'Predicting Protein Secondary Structure with Markov Models'. in Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005).

APA

Fischer, P., Larsen, S., & Thomsen, C. (2004). Predicting Protein Secondary Structure with Markov Models. In Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005).

CBE

Fischer P, Larsen S, Thomsen C. 2004. Predicting Protein Secondary Structure with Markov Models. In Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005).

MLA

Fischer, Paul, Simon Larsen and Claus Thomsen "Predicting Protein Secondary Structure with Markov Models". Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005). 2004.

Vancouver

Fischer P, Larsen S, Thomsen C. Predicting Protein Secondary Structure with Markov Models. In Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005). 2004.

Author

Fischer, Paul; Larsen, Simon; Thomsen, Claus / Predicting Protein Secondary Structure with Markov Models.

Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005). 2004.

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2004

Bibtex

@inbook{7a6052581db543138557e485e20becb9,
title = "Predicting Protein Secondary Structure with Markov Models",
author = "Paul Fischer and Simon Larsen and Claus Thomsen",
year = "2004",
booktitle = "Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005)",

}

RIS

TY - GEN

T1 - Predicting Protein Secondary Structure with Markov Models

A1 - Fischer,Paul

A1 - Larsen,Simon

A1 - Thomsen,Claus

AU - Fischer,Paul

AU - Larsen,Simon

AU - Thomsen,Claus

PY - 2004

Y1 - 2004

N2 - The primary structure of a protein is the sequence of its amino acids. The secondary structure describes structural properties of the molecule such as which parts of it form sheets, helices or coils. Spacial and other properties are described by the higher order structures. The classification task we are considering here, is to predict the secondary structure from the primary one. To this end we train a Markov model on training data and then use it to classify parts of unknown protein sequences as sheets, helices or coils. We show how to exploit the directional information contained in the Markov model for this task. Classifications that are purely based on statistical models might not always be biologically meaningful. We present combinatorial methods to incorporate biological background knowledge to enhance the prediction performance.

AB - The primary structure of a protein is the sequence of its amino acids. The secondary structure describes structural properties of the molecule such as which parts of it form sheets, helices or coils. Spacial and other properties are described by the higher order structures. The classification task we are considering here, is to predict the secondary structure from the primary one. To this end we train a Markov model on training data and then use it to classify parts of unknown protein sequences as sheets, helices or coils. We show how to exploit the directional information contained in the Markov model for this task. Classifications that are purely based on statistical models might not always be biologically meaningful. We present combinatorial methods to incorporate biological background knowledge to enhance the prediction performance.

UR - http://www.imm.dtu.dk/pubdb/p.php?3568

BT - Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005)

T2 - Proceedings of 29th Annual Conference of the German Classification Society (GfKl 2005)

ER -