PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. / Koefoed Petersen, Rasmus; Benzon Larsen, Signe; Jensen, Ditte Marie; Christensen, Jane; Olsen, Anja; Loft, Steffen; Nellemann, Christine Lydia; Overvad, Kim; Kristiansen, Karsten; Tjønneland, Anne; Vogel, Ulla Birgitte.

In: Cancer Letters, Vol. 315, No. 1, 2012, p. 59-68.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Koefoed Petersen, R, Benzon Larsen, S, Jensen, DM, Christensen, J, Olsen, A, Loft, S, Nellemann, CL, Overvad, K, Kristiansen, K, Tjønneland, A & Vogel, UB 2012, 'PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer' Cancer Letters, vol 315, no. 1, pp. 59-68., 10.1016/j.canlet.2011.10.009

APA

Koefoed Petersen, R., Benzon Larsen, S., Jensen, D. M., Christensen, J., Olsen, A., Loft, S., ... Vogel, U. B. (2012). PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Letters, 315(1), 59-68. 10.1016/j.canlet.2011.10.009

CBE

Koefoed Petersen R, Benzon Larsen S, Jensen DM, Christensen J, Olsen A, Loft S, Nellemann CL, Overvad K, Kristiansen K, Tjønneland A, Vogel UB. 2012. PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Letters. 315(1):59-68. Available from: 10.1016/j.canlet.2011.10.009

MLA

Vancouver

Koefoed Petersen R, Benzon Larsen S, Jensen DM, Christensen J, Olsen A, Loft S et al. PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Letters. 2012;315(1):59-68. Available from: 10.1016/j.canlet.2011.10.009

Author

Koefoed Petersen, Rasmus; Benzon Larsen, Signe; Jensen, Ditte Marie; Christensen, Jane; Olsen, Anja; Loft, Steffen; Nellemann, Christine Lydia; Overvad, Kim; Kristiansen, Karsten; Tjønneland, Anne; Vogel, Ulla Birgitte / PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer.

In: Cancer Letters, Vol. 315, No. 1, 2012, p. 59-68.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{13420ec3f03a4101b2f4f464d2f8b44b,
title = "PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer",
publisher = "Elsevier Ireland Ltd",
author = "{Koefoed Petersen}, Rasmus and {Benzon Larsen}, Signe and Jensen, {Ditte Marie} and Jane Christensen and Anja Olsen and Steffen Loft and Nellemann, {Christine Lydia} and Kim Overvad and Karsten Kristiansen and Anne Tjønneland and Vogel, {Ulla Birgitte}",
year = "2012",
doi = "10.1016/j.canlet.2011.10.009",
volume = "315",
number = "1",
pages = "59--68",
journal = "Cancer Letters",
issn = "0304-3835",

}

RIS

TY - JOUR

T1 - PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

A1 - Koefoed Petersen,Rasmus

A1 - Benzon Larsen,Signe

A1 - Jensen,Ditte Marie

A1 - Christensen,Jane

A1 - Olsen,Anja

A1 - Loft,Steffen

A1 - Nellemann,Christine Lydia

A1 - Overvad,Kim

A1 - Kristiansen,Karsten

A1 - Tjønneland,Anne

A1 - Vogel,Ulla Birgitte

AU - Koefoed Petersen,Rasmus

AU - Benzon Larsen,Signe

AU - Jensen,Ditte Marie

AU - Christensen,Jane

AU - Olsen,Anja

AU - Loft,Steffen

AU - Nellemann,Christine Lydia

AU - Overvad,Kim

AU - Kristiansen,Karsten

AU - Tjønneland,Anne

AU - Vogel,Ulla Birgitte

PB - Elsevier Ireland Ltd

PY - 2012

Y1 - 2012

N2 - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro12Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.

AB - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro12Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.

U2 - 10.1016/j.canlet.2011.10.009

DO - 10.1016/j.canlet.2011.10.009

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

VL - 315

SP - 59

EP - 68

ER -