PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
Publication: Research - peer-review › Journal article – Annual report year: 2012
Standard
PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. / Koefoed Petersen, Rasmus; Benzon Larsen, Signe; Jensen, Ditte Marie; Christensen, Jane; Olsen, Anja; Loft, Steffen; Nellemann, Christine Lydia; Overvad, Kim; Kristiansen, Karsten; Tjønneland, Anne; Vogel, Ulla Birgitte.
In: Cancer Letters, Vol. 315, No. 1, 2012, p. 59-68.Publication: Research - peer-review › Journal article – Annual report year: 2012
Harvard
APA
CBE
MLA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
A1 - Koefoed Petersen,Rasmus
A1 - Benzon Larsen,Signe
A1 - Jensen,Ditte Marie
A1 - Christensen,Jane
A1 - Olsen,Anja
A1 - Loft,Steffen
A1 - Nellemann,Christine Lydia
A1 - Overvad,Kim
A1 - Kristiansen,Karsten
A1 - Tjønneland,Anne
A1 - Vogel,Ulla Birgitte
AU - Koefoed Petersen,Rasmus
AU - Benzon Larsen,Signe
AU - Jensen,Ditte Marie
AU - Christensen,Jane
AU - Olsen,Anja
AU - Loft,Steffen
AU - Nellemann,Christine Lydia
AU - Overvad,Kim
AU - Kristiansen,Karsten
AU - Tjønneland,Anne
AU - Vogel,Ulla Birgitte
PB - Elsevier Ireland Ltd
PY - 2012
Y1 - 2012
N2 - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro12Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.
AB - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro12Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.
U2 - 10.1016/j.canlet.2011.10.009
DO - 10.1016/j.canlet.2011.10.009
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
VL - 315
SP - 59
EP - 68
ER -