Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Chronic lung infection by mucoid Pseudomonas aeruginosa is one of the major pathologic features in patients with cystic fibrosis. Mucoid P. aeruginosa is notorious for its biofilm forming capability and resistance to immune attacks. In this study, the roles of extracellular polymeric substances from biofilms formed by mucoid P. aeruginosa were investigated. Alginate is not an essential structure component for mucoid P. aeruginosa biofilms. Genetic studies revealed that Pel and Psl polysaccharides serve as essential scaffold and mediate macrocolony formation in mucoid P. aeruginosa biofilms. The Psl polysaccharide is more important than Pel polysaccharide in mucoid P. aeruginosa biofilm structure maintenance and phagocytosis resistance. The polysaccharides were further found to protect mucoid P. aeruginosa strain from host immune clearance in a mouse model of acute lung infection.
Original languageEnglish
JournalF E M S Immunology and Medical Microbiology
Publication date2012
Volume65
Issue2
Pages366-376
ISSN0928-8244
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 7
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