Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. / Andersen, Vibeke; Christensen, Jane; Overvad, Kim; Tjønneland, Anne; Vogel, Ulla Birgitte.

In: B M C Cancer, Vol. 10, 2010, p. 484.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Andersen, Vibeke; Christensen, Jane; Overvad, Kim; Tjønneland, Anne; Vogel, Ulla Birgitte / Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes.

In: B M C Cancer, Vol. 10, 2010, p. 484.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Bibtex

@article{2d4338af59c54a7da057e3216e0dbe4a,
title = "Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes",
publisher = "BioMed Central Ltd.",
author = "Vibeke Andersen and Jane Christensen and Kim Overvad and Anne Tjønneland and Vogel, {Ulla Birgitte}",
note = "This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2010",
doi = "10.1186/1471-2407-10-484",
volume = "10",
pages = "484",
journal = "B M C Cancer",
issn = "1471-2407",

}

RIS

TY - JOUR

T1 - Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

A1 - Andersen,Vibeke

A1 - Christensen,Jane

A1 - Overvad,Kim

A1 - Tjønneland,Anne

A1 - Vogel,Ulla Birgitte

AU - Andersen,Vibeke

AU - Christensen,Jane

AU - Overvad,Kim

AU - Tjønneland,Anne

AU - Vogel,Ulla Birgitte

PB - BioMed Central Ltd.

PY - 2010

Y1 - 2010

N2 - Background Transcription factors and nuclear receptors constitute a link between exposure to heterocyclic amines and polycyclic aromatic hydrocarbons from meat and tobacco smoke and colorectal cancer (CRC) risk. The aim of this study was to investigate if polymorphisms in nuclear factor kappa-B, pregnane X receptor, and liver X receptor were associated with risk of CRC, and to investigate possible interactions with lifestyle factors such as smoking, meat consumption, and NSAID use. Methods The polymorphisms nuclear factor kappa-B (NFkB, NFKB1) -94 insertion/deletion ATTG (rs28362491), pregnane X receptor (PXR, NR1I2) A-24381C (rs1523127), C8055T (rs2276707), A7635G (rs6785049), liver X receptor (LXR-β, NR1H3) C-rs1405655T, T-rs2695121C were assessed together with lifestyle factors in a nested case-cohort study of 378 CRC cases and 756 random participants from the Danish prospective Diet, Cancer and Health study of 57,053 persons. Results Carriers of NFkB -94deletion were at 1.45-fold higher risk of CRC than homozygous carriers of the insertion allele (incidence rate ratio (IRR) = 1.45, 95% confidence interval (95% CI): 1.10-1.92). There was interaction between this polymorphism and intake of red and processed meat in relation to CRC risk. Carriers of NFkB -94deletion were at 3% increased risk pr 25 gram meat per day (95% CI: 0.98-1.09) whereas homozygous carriers of the insertion were not at increased risk (p for interaction = 0.03). PXR and LXR polymorphisms were not associated with CRC risk. There was no interaction between use of nonsteroid antiinflammatory drugs (NSAID) or smoking status and NFkB, PXR or LXR polymorphisms. Conclusions A polymorphism in NFkB was associated with CRC risk and there was interaction between this polymorphism and meat intake in relation to CRC risk. This study suggests a role for NFkB in CRC aetiology.

AB - Background Transcription factors and nuclear receptors constitute a link between exposure to heterocyclic amines and polycyclic aromatic hydrocarbons from meat and tobacco smoke and colorectal cancer (CRC) risk. The aim of this study was to investigate if polymorphisms in nuclear factor kappa-B, pregnane X receptor, and liver X receptor were associated with risk of CRC, and to investigate possible interactions with lifestyle factors such as smoking, meat consumption, and NSAID use. Methods The polymorphisms nuclear factor kappa-B (NFkB, NFKB1) -94 insertion/deletion ATTG (rs28362491), pregnane X receptor (PXR, NR1I2) A-24381C (rs1523127), C8055T (rs2276707), A7635G (rs6785049), liver X receptor (LXR-β, NR1H3) C-rs1405655T, T-rs2695121C were assessed together with lifestyle factors in a nested case-cohort study of 378 CRC cases and 756 random participants from the Danish prospective Diet, Cancer and Health study of 57,053 persons. Results Carriers of NFkB -94deletion were at 1.45-fold higher risk of CRC than homozygous carriers of the insertion allele (incidence rate ratio (IRR) = 1.45, 95% confidence interval (95% CI): 1.10-1.92). There was interaction between this polymorphism and intake of red and processed meat in relation to CRC risk. Carriers of NFkB -94deletion were at 3% increased risk pr 25 gram meat per day (95% CI: 0.98-1.09) whereas homozygous carriers of the insertion were not at increased risk (p for interaction = 0.03). PXR and LXR polymorphisms were not associated with CRC risk. There was no interaction between use of nonsteroid antiinflammatory drugs (NSAID) or smoking status and NFkB, PXR or LXR polymorphisms. Conclusions A polymorphism in NFkB was associated with CRC risk and there was interaction between this polymorphism and meat intake in relation to CRC risk. This study suggests a role for NFkB in CRC aetiology.

U2 - 10.1186/1471-2407-10-484

DO - 10.1186/1471-2407-10-484

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

VL - 10

SP - 484

ER -