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Plasmodium falciparum merozoite surface protein 1 - Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte. / Hoessli, D.C.; Poincelet, M.; Gupta, Ramneek; Ilangumaran, S.; -ud-Din, Nasir.

In: European journal of biochemistry, Vol. 270, No. 2, 2003, p. 366-375.

Publication: Research - peer-reviewJournal article – Annual report year: 2003

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Hoessli, D.C.; Poincelet, M.; Gupta, Ramneek; Ilangumaran, S.; -ud-Din, Nasir / Plasmodium falciparum merozoite surface protein 1 - Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte.

In: European journal of biochemistry, Vol. 270, No. 2, 2003, p. 366-375.

Publication: Research - peer-reviewJournal article – Annual report year: 2003

Bibtex

@article{47413842872b41de830732999c49a3ce,
title = "Plasmodium falciparum merozoite surface protein 1 - Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte",
publisher = "Springer Verlag",
author = "D.C. Hoessli and M. Poincelet and Ramneek Gupta and S. Ilangumaran and Nasir -ud-Din",
year = "2003",
volume = "270",
number = "2",
pages = "366--375",
journal = "European journal of biochemistry",
issn = "0014-2956",

}

RIS

TY - JOUR

T1 - Plasmodium falciparum merozoite surface protein 1 - Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte

A1 - Hoessli,D.C.

A1 - Poincelet,M.

A1 - Gupta,Ramneek

A1 - Ilangumaran,S.

A1 - -ud-Din,Nasir

AU - Hoessli,D.C.

AU - Poincelet,M.

AU - Gupta,Ramneek

AU - Ilangumaran,S.

AU - -ud-Din,Nasir

PB - Springer Verlag

PY - 2003

Y1 - 2003

N2 - In addition to the major carbohydrate moieties of the glycosylphosphatidylinositol (GPI) anchor, we report that Plasmodium falciparum merozoite surface protein 1 (MSP-1) bears O-GlcNAc modifications predominantly in beta-anomeric configuration, in both the C- and N-terminal portions of the protein. Subcellular fractionation of parasitized erythrocytes in the late trophozoite/schizont stage reveals that GPI-anchored C-terminal fragments of MSP-1 are recovered in Triton X-100 resistant, low-density membrane fractions. Our results suggest that O -GlcNAc-modified MSP-1 N-terminal fragments tend to localize within the parasitophorous vacuolar membrane while GPI-anchored MSP-1 C-terminal fragments associate with low-density, Triton X-100 resistant membrane domains (rafts), redistribute in the parasitized erythrocyte and are eventually shed as membrane vesicles that also contain the endogenous, GPI-linked CD59.

AB - In addition to the major carbohydrate moieties of the glycosylphosphatidylinositol (GPI) anchor, we report that Plasmodium falciparum merozoite surface protein 1 (MSP-1) bears O-GlcNAc modifications predominantly in beta-anomeric configuration, in both the C- and N-terminal portions of the protein. Subcellular fractionation of parasitized erythrocytes in the late trophozoite/schizont stage reveals that GPI-anchored C-terminal fragments of MSP-1 are recovered in Triton X-100 resistant, low-density membrane fractions. Our results suggest that O -GlcNAc-modified MSP-1 N-terminal fragments tend to localize within the parasitophorous vacuolar membrane while GPI-anchored MSP-1 C-terminal fragments associate with low-density, Triton X-100 resistant membrane domains (rafts), redistribute in the parasitized erythrocyte and are eventually shed as membrane vesicles that also contain the endogenous, GPI-linked CD59.

JO - European journal of biochemistry

JF - European journal of biochemistry

SN - 0014-2956

IS - 2

VL - 270

SP - 366

EP - 375

ER -