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Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149 : F4. / Jensen, G.M.; Lykkesfeldt, J.; Frydendahl, K.; Møller, Kristian; Svendsen, O.

In: American Journal of Veterinary Research, Vol. 67, No. 4, 2006, p. 648-653.

Publication: Research - peer-reviewJournal article – Annual report year: 2006

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Jensen, G.M.; Lykkesfeldt, J.; Frydendahl, K.; Møller, Kristian; Svendsen, O. / Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149 : F4.

In: American Journal of Veterinary Research, Vol. 67, No. 4, 2006, p. 648-653.

Publication: Research - peer-reviewJournal article – Annual report year: 2006

Bibtex

@article{5e0c69ec101846d58849521b01f46b9b,
title = "Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149 : F4",
publisher = "American Veterinary Medical Association",
author = "G.M. Jensen and J. Lykkesfeldt and K. Frydendahl and Kristian Møller and O. Svendsen",
year = "2006",
doi = "10.2460/ajvr.67.4.648",
volume = "67",
number = "4",
pages = "648--653",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",

}

RIS

TY - JOUR

T1 - Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149 : F4

A1 - Jensen,G.M.

A1 - Lykkesfeldt,J.

A1 - Frydendahl,K.

A1 - Møller,Kristian

A1 - Svendsen,O.

AU - Jensen,G.M.

AU - Lykkesfeldt,J.

AU - Frydendahl,K.

AU - Møller,Kristian

AU - Svendsen,O.

PB - American Veterinary Medical Association

PY - 2006

Y1 - 2006

N2 - Objective-To measure effects of Escherichia coli 0149:F4-induced diarrhea on water consumption and pharmacokinetics of amoxicillin after administration in drinking water. Animals-24 recently weaned 24- to 28-day-old crossbred pigs. Procedure-10 pigs were inoculated with E coli O149:F4; all 10 pigs subsequently developed diarrhea. Pigs were medicated by administration of amoxicillin in the drinking water (0.75 mg/mL) for a 4-hour period on 2 consecutive days. Fourteen age-matched noninfected healthy pigs (control group) were medicated in a similar manner. Blood samples were obtained from both groups daily, and plasma concentrations of amoxicillin were analyzed by use of high-performance liquid chromatography. Results-Diarrhea reduced the area under the plasma concentration-versus-time curve (AUC) and maximum plasma concentration (C-max) of amoxicillin on the first day of medication by 56% and 63%, respectively. The AUC of amoxicillin on the second day of medication for diarrheic pigs did not differ significantly from that of control pigs on the first day of medication. Conclusions and Clinical Relevance-E coli-induced diarrhea reduced the AUC of amoxicillin and time that plasma concentration of amoxicillin was > 0.025 mu g/mL and, hence, less likely to have a therapeutic effect on the first day of administration in drinking water. On the assumption that plasma concentrations may indirectly reflect concentrations at the site of infection, analysis of our results suggests that higher doses of amoxicillin may be appropriate for administration in drinking water during a 4-hour period on the first day that pigs have diarrhea attributable to E coli 0149:F4.

AB - Objective-To measure effects of Escherichia coli 0149:F4-induced diarrhea on water consumption and pharmacokinetics of amoxicillin after administration in drinking water. Animals-24 recently weaned 24- to 28-day-old crossbred pigs. Procedure-10 pigs were inoculated with E coli O149:F4; all 10 pigs subsequently developed diarrhea. Pigs were medicated by administration of amoxicillin in the drinking water (0.75 mg/mL) for a 4-hour period on 2 consecutive days. Fourteen age-matched noninfected healthy pigs (control group) were medicated in a similar manner. Blood samples were obtained from both groups daily, and plasma concentrations of amoxicillin were analyzed by use of high-performance liquid chromatography. Results-Diarrhea reduced the area under the plasma concentration-versus-time curve (AUC) and maximum plasma concentration (C-max) of amoxicillin on the first day of medication by 56% and 63%, respectively. The AUC of amoxicillin on the second day of medication for diarrheic pigs did not differ significantly from that of control pigs on the first day of medication. Conclusions and Clinical Relevance-E coli-induced diarrhea reduced the AUC of amoxicillin and time that plasma concentration of amoxicillin was > 0.025 mu g/mL and, hence, less likely to have a therapeutic effect on the first day of administration in drinking water. On the assumption that plasma concentrations may indirectly reflect concentrations at the site of infection, analysis of our results suggests that higher doses of amoxicillin may be appropriate for administration in drinking water during a 4-hour period on the first day that pigs have diarrhea attributable to E coli 0149:F4.

U2 - 10.2460/ajvr.67.4.648

DO - 10.2460/ajvr.67.4.648

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 4

VL - 67

SP - 648

EP - 653

ER -