TY - GEN

T1 - Overnight Control of Blood Glucose in People with Type 1 Diabetes

A1 - Boiroux,Dimitri

A1 - Duun-Henriksen,Anne Katrine

A1 - Schmidt,Signe

A1 - Nørgaard,Kirsten

A1 - Madsbad,Sten

A1 - Skyggebjerg,Ole

A1 - Jensen,Peter Ruhdal

A1 - Poulsen,Niels Kjølstad

A1 - Madsen,Henrik

A1 - Jørgensen,John Bagterp

AU - Boiroux,Dimitri

AU - Duun-Henriksen,Anne Katrine

AU - Schmidt,Signe

AU - Nørgaard,Kirsten

AU - Madsbad,Sten

AU - Skyggebjerg,Ole

AU - Jensen,Peter Ruhdal

AU - Poulsen,Niels Kjølstad

AU - Madsen,Henrik

AU - Jørgensen,John Bagterp

PY - 2012

Y1 - 2012

N2 - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

AB - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

BT - Proceedings of the 8th IFAC Symposium on Biological and Medical Systems

T2 - Proceedings of the 8th IFAC Symposium on Biological and Medical Systems

ER -