Overnight Control of Blood Glucose in People with Type 1 Diabetes

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

Standard

Overnight Control of Blood Glucose in People with Type 1 Diabetes. / Boiroux, Dimitri; Duun-Henriksen, Anne Katrine; Schmidt, Signe; Nørgaard, Kirsten; Madsbad, Sten; Skyggebjerg, Ole; Jensen, Peter Ruhdal; Poulsen, Niels Kjølstad; Madsen, Henrik; Jørgensen, John Bagterp.

Biological and Medical Systems. Vol. 8 2012. p. 73-78 (IFAC Proceedings Volumes (IFAC-PapersOnline) ).

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

Harvard

Boiroux, D, Duun-Henriksen, AK, Schmidt, S, Nørgaard, K, Madsbad, S, Skyggebjerg, O, Jensen, PR, Poulsen, NK, Madsen, H & Jørgensen, JB 2012, 'Overnight Control of Blood Glucose in People with Type 1 Diabetes'. in Biological and Medical Systems. vol. 8, pp. 73-78. IFAC Proceedings Volumes (IFAC-PapersOnline) , , 10.3182/20120829-3-HU-2029.00106

APA

Boiroux, D., Duun-Henriksen, A. K., Schmidt, S., Nørgaard, K., Madsbad, S., Skyggebjerg, O., Jensen, P. R., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2012). Overnight Control of Blood Glucose in People with Type 1 Diabetes. In Biological and Medical Systems. (Vol. 8, pp. 73-78). (IFAC Proceedings Volumes (IFAC-PapersOnline) ). 10.3182/20120829-3-HU-2029.00106

CBE

Boiroux D, Duun-Henriksen AK, Schmidt S, Nørgaard K, Madsbad S, Skyggebjerg O, Jensen PR, Poulsen NK, Madsen H, Jørgensen JB. 2012. Overnight Control of Blood Glucose in People with Type 1 Diabetes. In Biological and Medical Systems. pp. 73-78. (IFAC Proceedings Volumes (IFAC-PapersOnline) ). Available from: 10.3182/20120829-3-HU-2029.00106

MLA

Boiroux, Dimitri et al. "Overnight Control of Blood Glucose in People with Type 1 Diabetes". Biological and Medical Systems. 2012. 73-78. (IFAC Proceedings Volumes (IFAC-PapersOnline) ). Available: 10.3182/20120829-3-HU-2029.00106

Vancouver

Boiroux D, Duun-Henriksen AK, Schmidt S, Nørgaard K, Madsbad S, Skyggebjerg O et al. Overnight Control of Blood Glucose in People with Type 1 Diabetes. In Biological and Medical Systems. Vol. 8. 2012. p. 73-78. (IFAC Proceedings Volumes (IFAC-PapersOnline) ). Available from: 10.3182/20120829-3-HU-2029.00106

Author

Boiroux, Dimitri; Duun-Henriksen, Anne Katrine; Schmidt, Signe; Nørgaard, Kirsten; Madsbad, Sten; Skyggebjerg, Ole; Jensen, Peter Ruhdal; Poulsen, Niels Kjølstad; Madsen, Henrik; Jørgensen, John Bagterp / Overnight Control of Blood Glucose in People with Type 1 Diabetes.

Biological and Medical Systems. Vol. 8 2012. p. 73-78 (IFAC Proceedings Volumes (IFAC-PapersOnline) ).

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

Bibtex

@inbook{d67d642e00f049ce88884925fd8f8df3,
title = "Overnight Control of Blood Glucose in People with Type 1 Diabetes",
author = "Dimitri Boiroux and Duun-Henriksen, {Anne Katrine} and Signe Schmidt and Kirsten Nørgaard and Sten Madsbad and Ole Skyggebjerg and Jensen, {Peter Ruhdal} and Poulsen, {Niels Kjølstad} and Henrik Madsen and Jørgensen, {John Bagterp}",
year = "2012",
doi = "10.3182/20120829-3-HU-2029.00106",
volume = "8",
isbn = "978-3-902823-10-6",
series = "IFAC Proceedings Volumes (IFAC-PapersOnline)",
pages = "73-78",
booktitle = "Biological and Medical Systems",

}

RIS

TY - GEN

T1 - Overnight Control of Blood Glucose in People with Type 1 Diabetes

A1 - Boiroux,Dimitri

A1 - Duun-Henriksen,Anne Katrine

A1 - Schmidt,Signe

A1 - Nørgaard,Kirsten

A1 - Madsbad,Sten

A1 - Skyggebjerg,Ole

A1 - Jensen,Peter Ruhdal

A1 - Poulsen,Niels Kjølstad

A1 - Madsen,Henrik

A1 - Jørgensen,John Bagterp

AU - Boiroux,Dimitri

AU - Duun-Henriksen,Anne Katrine

AU - Schmidt,Signe

AU - Nørgaard,Kirsten

AU - Madsbad,Sten

AU - Skyggebjerg,Ole

AU - Jensen,Peter Ruhdal

AU - Poulsen,Niels Kjølstad

AU - Madsen,Henrik

AU - Jørgensen,John Bagterp

PY - 2012

Y1 - 2012

N2 - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

AB - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

U2 - 10.3182/20120829-3-HU-2029.00106

DO - 10.3182/20120829-3-HU-2029.00106

SN - 978-3-902823-10-6

VL - 8

BT - Biological and Medical Systems

T2 - Biological and Medical Systems

T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)

T3 - en_GB

SP - 73

EP - 78

ER -