Overnight Control of Blood Glucose in People with Type 1 Diabetes

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2012

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In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.
Original languageEnglish
Title of host publicationBiological and Medical Systems
Volume8
Publication date2012
Pages73-78
ISBN (print)978-3-902823-10-6
DOIs
StatePublished

Conference

Conference8th IFAC Symposium on Biological and Medical Systems
CountryHungary
CityBudapest
Period29/08/1231/08/12
Internet addresshttp://bms.iit.bme.hu/
NameIFAC Proceedings Volumes (IFAC-PapersOnline)
CitationsWeb of Science® Times Cited: No match on DOI
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