Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study
Publication: Research - peer-review › Journal article – Annual report year: 2011
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Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study. / Okkels, Fridolin; Dufva, Martin; Bruus, Henrik.
In: P L o S One, Vol. 6, No. 1, 2011, p. e14574.Publication: Research - peer-review › Journal article – Annual report year: 2011
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TY - JOUR
T1 - Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study
A1 - Okkels,Fridolin
A1 - Dufva,Martin
A1 - Bruus,Henrik
AU - Okkels,Fridolin
AU - Dufva,Martin
AU - Bruus,Henrik
PB - Public Library of Science
PY - 2011
Y1 - 2011
N2 - In recent years, the interest in small-scale bio-reactors has increased dramatically. To ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continually feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for, e. g., cell culturing and analysis and in feeding bio-arrays.
AB - In recent years, the interest in small-scale bio-reactors has increased dramatically. To ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continually feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for, e. g., cell culturing and analysis and in feeding bio-arrays.
U2 - 10.1371/journal.pone.0014574
DO - 10.1371/journal.pone.0014574
JO - P L o S One
JF - P L o S One
SN - 1932-6203
IS - 1
VL - 6
SP - e14574
ER -