Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study. / Okkels, Fridolin; Dufva, Martin; Bruus, Henrik.

In: P L o S One, Vol. 6, No. 1, 2011, p. e14574.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Okkels, Fridolin; Dufva, Martin; Bruus, Henrik / Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study.

In: P L o S One, Vol. 6, No. 1, 2011, p. e14574.

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Bibtex

@article{aaf561f9d1864c7c979ae74a2206828f,
title = "Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study",
publisher = "Public Library of Science",
author = "Fridolin Okkels and Martin Dufva and Henrik Bruus",
year = "2011",
doi = "10.1371/journal.pone.0014574",
volume = "6",
number = "1",
pages = "e14574",
journal = "P L o S One",
issn = "1932-6203",

}

RIS

TY - JOUR

T1 - Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

A1 - Okkels,Fridolin

A1 - Dufva,Martin

A1 - Bruus,Henrik

AU - Okkels,Fridolin

AU - Dufva,Martin

AU - Bruus,Henrik

PB - Public Library of Science

PY - 2011

Y1 - 2011

N2 - In recent years, the interest in small-scale bio-reactors has increased dramatically. To ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continually feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for, e. g., cell culturing and analysis and in feeding bio-arrays.

AB - In recent years, the interest in small-scale bio-reactors has increased dramatically. To ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continually feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for, e. g., cell culturing and analysis and in feeding bio-arrays.

U2 - 10.1371/journal.pone.0014574

DO - 10.1371/journal.pone.0014574

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 1

VL - 6

SP - e14574

ER -