Optimal Homogenization of Perfusion Flows in Microfluidic Bio-Reactors: A Numerical Study

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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In recent years, the interest in small-scale bio-reactors has increased dramatically. To ensure homogeneous conditions within the complete area of perfused microfluidic bio-reactors, we develop a general design of a continually feed bio-reactor with uniform perfusion flow. This is achieved by introducing a specific type of perfusion inlet to the reaction area. The geometry of these inlets are found using the methods of topology optimization and shape optimization. The results are compared with two different analytic models, from which a general parametric description of the design is obtained and tested numerically. Such a parametric description will generally be beneficial for the design of a broad range of microfluidic bioreactors used for, e. g., cell culturing and analysis and in feeding bio-arrays.
Original languageEnglish
JournalP L o S One
Publication date2011
Volume6
Issue1
Pagese14574
ISSN1932-6203
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 3
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