Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry
Publication: Research - peer-review › Journal article – Annual report year: 2012
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Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. / Haahr, M. E.; Rasmussen, Peter Mondrup; Madsen, K.; Marner, L.; Ratner, C.; Gillings, N.; Baaré, W. F. C.; Knudsen, G. M.
In: NeuroImage, Vol. 61, No. 4, 2012, p. 884-888.Publication: Research - peer-review › Journal article – Annual report year: 2012
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TY - JOUR
T1 - Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry
AU - Haahr,M. E.
AU - Rasmussen,Peter Mondrup
AU - Madsen,K.
AU - Marner,L.
AU - Ratner,C.
AU - Gillings,N.
AU - Baaré,W. F. C.
AU - Knudsen,G. M.
PY - 2012
Y1 - 2012
N2 - The neurobiology underlying obesity is not fully understood. The neurotransmitter serotonin (5-HT) is established as a satiety-generating signal, but its rewarding role in feeding is less well elucidated. From animal experiments there is now evidence that the 5-HT4 receptor (5-HT4R) is involved in food intake, and that pharmacological or genetic manipulation of the receptor in reward-related brain areas alters food intake.Here, we used positron emission tomography in humans to examine the association between cerebral 5-HT4Rs and common obesity.We found in humans a strong positive association between body mass index and the 5-HT4R density bilaterally in the two reward ‘hot spots’ nucleus accumbens and ventral pallidum, and additionally in the left hippocampal region and orbitofrontal cortex.These findings suggest that the 5-HT4R is critically involved in reward circuits that regulate people's food intake. They also suggest that pharmacological stimulation of the cerebral 5-HT4R may reduce reward-related overeating in humans.
AB - The neurobiology underlying obesity is not fully understood. The neurotransmitter serotonin (5-HT) is established as a satiety-generating signal, but its rewarding role in feeding is less well elucidated. From animal experiments there is now evidence that the 5-HT4 receptor (5-HT4R) is involved in food intake, and that pharmacological or genetic manipulation of the receptor in reward-related brain areas alters food intake.Here, we used positron emission tomography in humans to examine the association between cerebral 5-HT4Rs and common obesity.We found in humans a strong positive association between body mass index and the 5-HT4R density bilaterally in the two reward ‘hot spots’ nucleus accumbens and ventral pallidum, and additionally in the left hippocampal region and orbitofrontal cortex.These findings suggest that the 5-HT4R is critically involved in reward circuits that regulate people's food intake. They also suggest that pharmacological stimulation of the cerebral 5-HT4R may reduce reward-related overeating in humans.
KW - PET
KW - Serotonin 4 receptor
KW - Neuroimaging
KW - Obesity
KW - Reward
U2 - 10.1016/j.neuroimage.2012.03.050
DO - 10.1016/j.neuroimage.2012.03.050
M3 - Journal article
VL - 61
SP - 884
EP - 888
JO - NeuroImage
T2 - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 4
ER -