Nucleotide Metabolism
Publication: Research - peer-review › Book chapter – Annual report year: 2011
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Nucleotide Metabolism. / Martinussen, Jan; Willemoës, M.; Kilstrup, Mogens.
In: Comprehensive Biotechnology. ed. / Murray Moo-Young. Vol. 1 2. ed. Elsevier Science, 2011. p. 91-107.Publication: Research - peer-review › Book chapter – Annual report year: 2011
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TY - CHAP
T1 - Nucleotide Metabolism
A1 - Martinussen,Jan
A1 - Willemoës,M.
A1 - Kilstrup,Mogens
AU - Martinussen,Jan
AU - Willemoës,M.
AU - Kilstrup,Mogens
PB - Elsevier Science
PY - 2011
Y1 - 2011
N2 - Metabolic pathways are connected through their utilization of nucleotides as supplier of energy, allosteric effectors, and their role in activation of intermediates. Therefore, any attempt to exploit a given living organism in a biotechnological process will have an impact on nucleotide metabolism and vice versa. Here, we provide an overview of the pyrimidine and purine biosynthesis, the interconversion pathways, the formation of deoxyribonucleotides, and the salvage reactions used in the utilization of exogenous precursors. The enzymatic and genetic regulation of these pathways are addressed. The aim of this article is to provide knowledge of nucleotide metabolism and its regulation to facilitate interpretation of data arising from genetics, proteomics, and transcriptomics in connection with biotechnological processes and beyond.
AB - Metabolic pathways are connected through their utilization of nucleotides as supplier of energy, allosteric effectors, and their role in activation of intermediates. Therefore, any attempt to exploit a given living organism in a biotechnological process will have an impact on nucleotide metabolism and vice versa. Here, we provide an overview of the pyrimidine and purine biosynthesis, the interconversion pathways, the formation of deoxyribonucleotides, and the salvage reactions used in the utilization of exogenous precursors. The enzymatic and genetic regulation of these pathways are addressed. The aim of this article is to provide knowledge of nucleotide metabolism and its regulation to facilitate interpretation of data arising from genetics, proteomics, and transcriptomics in connection with biotechnological processes and beyond.
KW - Nucleotide salvage
KW - ATP
KW - dATP
KW - GTP
KW - Purines
KW - dGTP
KW - Nucleotide biosynthesis
KW - UTP
KW - dCTP
KW - Pyrimidines
KW - dTTP
KW - Nucleotide interconversion
KW - CTP
KW - Regulation of gene expression
UR - http://www.sciencedirect.com/science/referenceworks/9780080885049#ancsec1
SN - 978-0-08-088504-9
VL - 1
BT - Comprehensive Biotechnology
T2 - Comprehensive Biotechnology
A2 - Moo-Young,Murray
ED - Moo-Young,Murray
SP - 91
EP - 107
ER -