Nonlinear Denoising and Analysis of Neuroimages With Kernel Principal Component Analysis and Pre-Image Estimation
Publication: Research - peer-review › Journal article – Annual report year: 2012
We investigate the use of kernel principal component analysis (PCA) and the inverse problem known as pre-image estimation in neuroimaging: i) We explore kernel PCA and pre-image estimation as a means for image denoising as part of the image preprocessing pipeline. Evaluation of the denoising procedure is performed within a data-driven split-half evaluation framework. ii) We introduce manifold navigation for exploration of a nonlinear data manifold, and illustrate how pre-image estimation can be used to generate brain maps in the continuum between experimentally defined brain states/classes. We base these illustrations on two fMRI BOLD data sets — one from a simple finger tapping experiment and the other from an experiment on object recognition in the ventral temporal lobe.
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- Multivariate analysis, Classification, Decoding, Nonlinear modeling, Kernel PCA, Pre-image estimation, NPAIRS resampling