Network Medicine Strikes a Blow against Breast Cancer

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
Original languageEnglish
JournalCell
Publication date2012
Volume149
Issue4
Pages731-733
ISSN0092-8674
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 17
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