Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid Is Skewed by Maternal Atopy

Publication: Research - peer-reviewJournal article – Annual report year: 2012

  • Author: Folsgaard, Nilofar V.

    Copenhagen University Hospital

  • Author: Chawes, Bo L.

    Copenhagen University Hospital

  • Author: Rasmussen, Morten A.

    University of Copenhagen

  • Author: Bischoff, Anne L.

    Copenhagen University Hospital

  • Author: Carson, Charlotte G.

    Copenhagen University Hospital

  • Author: Stokholm, Jakob

    Copenhagen University Hospital

  • Author: Pedersen, Louise

    Copenhagen University Hospital

  • Author: Hansel, Trevor T.

    Imperial College London

  • Author: Bonnelykke, Klaus

    Copenhagen University Hospital

  • Author: Pedersen, Susanne Brix

    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Søltofts Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Bisgaard, Hans

    Copenhagen University Hospital

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Rationale: Heredity from mother or father may impact differently in complex diseases, such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Objectives: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Methods: Eighteen cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort. Measurements and Main Results: Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015). Conclusions: Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.
Original languageEnglish
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number3
Pages (from-to)275-280
StatePublished - 2012
CitationsWeb of Science® Times Cited: 28
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ID: 6681319