Nanofluidic Devices with Two Pores in Series for Resistive-Pulse Sensing of Single Virus Capsids

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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We report fabrication and characterization of nanochannel devices with two nanopores in series for resistive-pulse sensing of hepatitis B virus (HBV) capsids. The nanochannel and two pores are patterned by electron beam lithography between two microchannels and etched by reactive ion etching. The two nanopores are 50-nm wide, 50-nm deep, and 40-nm long and are spaced 2.0-μm apart. The nanochannel that brackets the two pores is 20 wider (1 μm) to reduce the electrical resistance adjacent to the two pores and to ensure the current returns to its baseline value between resistive-pulse events. Average pulse amplitudes differ by
Original languageEnglish
JournalAnalytical Chemistry
Publication date2011
Volume83
Pages9573-9578
ISSN0003-2700
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 15
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