Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa. / Marvig, Rasmus Lykke; Søndergaard, Mette S. R.; Pedersen, Søren Damkiær; Høiby, Niels; Johansen, Helle Krogh; Molin, Søren; Jelsbak, Lars.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 8, 2012, p. 4519-4521.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Author

Marvig, Rasmus Lykke; Søndergaard, Mette S. R.; Pedersen, Søren Damkiær; Høiby, Niels; Johansen, Helle Krogh; Molin, Søren; Jelsbak, Lars / Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 8, 2012, p. 4519-4521.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{200e99ff47184b5a849c4f5b04cb5f0e,
title = "Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa",
publisher = "American Society for Microbiology",
author = "Marvig, {Rasmus Lykke} and Søndergaard, {Mette S. R.} and Pedersen, {Søren Damkiær} and Niels Høiby and Johansen, {Helle Krogh} and Søren Molin and Lars Jelsbak",
year = "2012",
doi = "10.1128/AAC.00630-12",
volume = "56",
number = "8",
pages = "4519--4521",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",

}

RIS

TY - JOUR

T1 - Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa

A1 - Marvig,Rasmus Lykke

A1 - Søndergaard,Mette S. R.

A1 - Pedersen,Søren Damkiær

A1 - Høiby,Niels

A1 - Johansen,Helle Krogh

A1 - Molin,Søren

A1 - Jelsbak,Lars

AU - Marvig,Rasmus Lykke

AU - Søndergaard,Mette S. R.

AU - Pedersen,Søren Damkiær

AU - Høiby,Niels

AU - Johansen,Helle Krogh

AU - Molin,Søren

AU - Jelsbak,Lars

PB - American Society for Microbiology

PY - 2012

Y1 - 2012

N2 - The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

AB - The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

U2 - 10.1128/AAC.00630-12

DO - 10.1128/AAC.00630-12

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 8

VL - 56

SP - 4519

EP - 4521

ER -