Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis

Publication: Research - peer-reviewJournal article – Annual report year: 2005

Without internal affiliation

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Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis. / Mathiesen, Henrik Kahr; Tscherning, Thomas; Sørensen, Per Soelberg; Larsson, Henrik B.W.; Rostrup, Egill; Paulson, Olaf B.; Hanson, Lars G.

In: Magnetic Resonance in Medicine, Vol. 53, No. 4, 2005, p. 750-759.

Publication: Research - peer-reviewJournal article – Annual report year: 2005

Harvard

Mathiesen, HK, Tscherning, T, Sørensen, PS, Larsson, HBW, Rostrup, E, Paulson, OB & Hanson, LG 2005, 'Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis' Magnetic Resonance in Medicine, vol 53, no. 4, pp. 750-759., 10.1002/mrm.20407

APA

Mathiesen, H. K., Tscherning, T., Sørensen, P. S., Larsson, H. B. W., Rostrup, E., Paulson, O. B., & Hanson, L. G. (2005). Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis. Magnetic Resonance in Medicine, 53(4), 750-759. 10.1002/mrm.20407

CBE

MLA

Vancouver

Mathiesen HK, Tscherning T, Sørensen PS, Larsson HBW, Rostrup E, Paulson OB et al. Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis. Magnetic Resonance in Medicine. 2005;53(4):750-759. Available from: 10.1002/mrm.20407

Author

Mathiesen, Henrik Kahr; Tscherning, Thomas; Sørensen, Per Soelberg; Larsson, Henrik B.W.; Rostrup, Egill; Paulson, Olaf B.; Hanson, Lars G. / Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis.

In: Magnetic Resonance in Medicine, Vol. 53, No. 4, 2005, p. 750-759.

Publication: Research - peer-reviewJournal article – Annual report year: 2005

Bibtex

@article{537b152b7d7d4f4c94101cf3f543be09,
title = "Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd.",
author = "Mathiesen, {Henrik Kahr} and Thomas Tscherning and Sørensen, {Per Soelberg} and Larsson, {Henrik B.W.} and Egill Rostrup and Paulson, {Olaf B.} and Hanson, {Lars G.}",
year = "2005",
doi = "10.1002/mrm.20407",
volume = "53",
number = "4",
pages = "750--759",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",

}

RIS

TY - JOUR

T1 - Multi-slice Echo-Planar Spectroscopic MR Imaging Provides Both Global and Local Metabolite Measures in Multiple Sclerosis

A1 - Mathiesen,Henrik Kahr

A1 - Tscherning,Thomas

A1 - Sørensen,Per Soelberg

A1 - Larsson,Henrik B.W.

A1 - Rostrup,Egill

A1 - Paulson,Olaf B.

A1 - Hanson,Lars G.

AU - Mathiesen,Henrik Kahr

AU - Tscherning,Thomas

AU - Sørensen,Per Soelberg

AU - Larsson,Henrik B.W.

AU - Rostrup,Egill

AU - Paulson,Olaf B.

AU - Hanson,Lars G.

PB - John/Wiley & Sons, Inc. John/Wiley & Sons Ltd.

PY - 2005

Y1 - 2005

N2 - MR spectroscopy (MRS) provides information about neuronal loss or dysfunction by measuring decreases in N-acetyl aspartate (NAA), a metabolite widely believed to be a marker of neuronal viability. In multiple sclerosis (MS), whole-brain NAA (WBNAA) has been suggested as a marker of disease progression and treatment efficacy in treatment trials, and the ability to measure NAA loss in specific brain regions early in the evolution of this disease may have prognostic value. Most spectroscopic studies to date have been limited to single voxels or nonlocalized measurements of WBNAA only, and longitudinal studies have often been hampered by standardization and reproducibility problems. Multi-slice echo-planar spectroscopic imaging (EPSI) is presented as a promising alternative to singlevoxel or nonlocalized spectroscopy for obtaining global metabolite estimates in MS. In the same session, measurements of metabolites in specific brain areas chosen after image acquisition (e.g., normal-appearing white matter (NAWM), gray matter(GM), and lesions) can be obtained. The identification and exclusion of regions that are inadequate for spectroscopic evaluation in global assessments can significantly improve quality and reproducibility, as demonstrated by a low within-subject variance in healthy controls. The reproducibility of the technique makes it a promising tool for future longitudinal spectroscopic studies of MS.<br/> Keyword: Multi-slice echo planar spectroscopic imaging,Multiple sclerosis,Normal-appearing white matter,Lesions,Whole-brain NAA,Gray matter

AB - MR spectroscopy (MRS) provides information about neuronal loss or dysfunction by measuring decreases in N-acetyl aspartate (NAA), a metabolite widely believed to be a marker of neuronal viability. In multiple sclerosis (MS), whole-brain NAA (WBNAA) has been suggested as a marker of disease progression and treatment efficacy in treatment trials, and the ability to measure NAA loss in specific brain regions early in the evolution of this disease may have prognostic value. Most spectroscopic studies to date have been limited to single voxels or nonlocalized measurements of WBNAA only, and longitudinal studies have often been hampered by standardization and reproducibility problems. Multi-slice echo-planar spectroscopic imaging (EPSI) is presented as a promising alternative to singlevoxel or nonlocalized spectroscopy for obtaining global metabolite estimates in MS. In the same session, measurements of metabolites in specific brain areas chosen after image acquisition (e.g., normal-appearing white matter (NAWM), gray matter(GM), and lesions) can be obtained. The identification and exclusion of regions that are inadequate for spectroscopic evaluation in global assessments can significantly improve quality and reproducibility, as demonstrated by a low within-subject variance in healthy controls. The reproducibility of the technique makes it a promising tool for future longitudinal spectroscopic studies of MS.<br/> Keyword: Multi-slice echo planar spectroscopic imaging,Multiple sclerosis,Normal-appearing white matter,Lesions,Whole-brain NAA,Gray matter

U2 - 10.1002/mrm.20407

DO - 10.1002/mrm.20407

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

VL - 53

SP - 750

EP - 759

ER -