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In large-scale fermentors, non-ideal mixing leads to the development of heterogeneous cell populations. This cell-to-cell variability may explain the differences in e.g. yields for large- and lab-scale cultivations. In this work the anaerobic growth
of Saccharomyces cerevisiae in a continuously run microbioreactor is simulated. A multiscale model consisting of the coupling of a population balance model, a kinetic model and a flow model was developed in order to predict simultaneously local concentrations of substrate (glucose), product (ethanol) and biomass, as well as the local cell size distributions.
Original languageEnglish
TitleProceedings of the 11th International Symposium on Process Systems Engineering
EditorsI.A. Karimi, Rajagopalan Srinivasan
PublisherElsevier Science
Publication date2012
Pages545-549
StatePublished

Conference

Conference11th International Symposium on Process Systems Engineering
CountrySingapore
Period15/07/1219/07/12
NameComputer Aided Chemical Engineering
Volume31
ISSN (Print)1570-7946

Keywords

  • Population balance model, computational fluid dynamics, Yeast, Microreactor, Fermentation
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