Modular microfluidic system as a model of cystic fibrosis airways

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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@article{8465d99239be4f5581f131f7ed31eb1a,
title = "Modular microfluidic system as a model of cystic fibrosis airways",
keywords = "Antibiotics, Bacteria, Cell culture, Oxygen",
publisher = "American Institute of Physics",
author = "Maciej Skolimowski and {Weiss Nielsen}, Martin and Fabien Abeille and Peder Skafte-Pedersen and David Sabourin and A. Fercher and D. Papkovsky and Søren Molin and Taboryski, {Rafael J.} and Claus Sternberg and Martin Dufva and Oliver Geschke and Jenny Emnéus",
note = "© 2012 American Institute of Physics",
year = "2012",
doi = "10.1063/1.4742911",
volume = "6",
number = "3",
pages = "034109",
journal = "Biomicrofluidics",
issn = "1932-1058",

}

RIS

TY - JOUR

T1 - Modular microfluidic system as a model of cystic fibrosis airways

A1 - Skolimowski,Maciej

A1 - Weiss Nielsen ,Martin

A1 - Abeille,Fabien

A1 - Skafte-Pedersen,Peder

A1 - Sabourin,David

A1 - Fercher,A.

A1 - Papkovsky,D.

A1 - Molin,Søren

A1 - Taboryski,Rafael J.

A1 - Sternberg,Claus

A1 - Dufva,Martin

A1 - Geschke,Oliver

A1 - Emnéus,Jenny

AU - Skolimowski,Maciej

AU - Weiss Nielsen ,Martin

AU - Abeille,Fabien

AU - Skafte-Pedersen,Peder

AU - Sabourin,David

AU - Fercher,A.

AU - Papkovsky,D.

AU - Molin,Søren

AU - Taboryski,Rafael J.

AU - Sternberg,Claus

AU - Dufva,Martin

AU - Geschke,Oliver

AU - Emnéus,Jenny

PB - American Institute of Physics

PY - 2012

Y1 - 2012

N2 - A modular microfluidic airways model system that can simulate the changes in oxygen tension in different compartments of the cystic fibrosis (CF) airways was designed, developed, and tested. The fully reconfigurable system composed of modules with different functionalities: multichannel peristaltic pumps, bubble traps, gas exchange chip, and cell culture chambers. We have successfully applied this system for studying the antibiotic therapy of Pseudomonas aeruginosa, the bacteria mainly responsible for morbidity and mortality in cystic fibrosis, in different oxygen environments. Furthermore, we have mimicked the bacterial reinoculation of the aerobic compartments (lower respiratory tract) from the anaerobic compartments (cystic fibrosis sinuses) following an antibiotic treatment. This effect is hypothesised as the one on the main reasons for recurrent lung infections in cystic fibrosis patients.

AB - A modular microfluidic airways model system that can simulate the changes in oxygen tension in different compartments of the cystic fibrosis (CF) airways was designed, developed, and tested. The fully reconfigurable system composed of modules with different functionalities: multichannel peristaltic pumps, bubble traps, gas exchange chip, and cell culture chambers. We have successfully applied this system for studying the antibiotic therapy of Pseudomonas aeruginosa, the bacteria mainly responsible for morbidity and mortality in cystic fibrosis, in different oxygen environments. Furthermore, we have mimicked the bacterial reinoculation of the aerobic compartments (lower respiratory tract) from the anaerobic compartments (cystic fibrosis sinuses) following an antibiotic treatment. This effect is hypothesised as the one on the main reasons for recurrent lung infections in cystic fibrosis patients.

KW - Antibiotics

KW - Bacteria

KW - Cell culture

KW - Oxygen

U2 - 10.1063/1.4742911

DO - 10.1063/1.4742911

JO - Biomicrofluidics

JF - Biomicrofluidics

SN - 1932-1058

IS - 3

VL - 6

SP - 034109

ER -