Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia

Publication: Research - peer-reviewJournal article – Annual report year: 2006

  • Author: Reidl, Juergen

    University of Heidelberg

  • Author: Borowski, Peter

    Max Planck Institut fuer Physik komplexer Systeme, Dresden

  • Author: Sensse, Anke

    Fritz Haber Institute of the Max Planck Society, Berlin

  • Author: Starke, Jens

    Dynamical systems, Department of Mathematics, Technical University of Denmark

  • Author: Zapotocky, Martin

    Max Planck Institut fuer Physik komplexer Systeme, Dresden

  • Author: Eiswirth, Markus

    Fritz Haber Institute of the Max Planck Society, Berlin

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We present a mathematical model for Ca oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
Original languageEnglish
JournalBiophysical Journal
Publication date2006
Volume90
Issue4
Pages1147-1155
ISSN0006-3495
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 28
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