Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers. Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice. Results:: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states. Conclusion: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.
Original languageEnglish
JournalBrain Stimulation
Volume12
Issue number2
Pages (from-to)251-255
ISSN1935-861X
DOIs
Publication statusPublished - 2018
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • LIPUS, Ultrasound transducer, Freely-moving, Neuromodulation
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