Methodological Approach for Modeling of Multienzyme in-pot Processes

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2011

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This paper presents a methodological approach for modeling multi-enzyme in-pot processes. The methodology is exemplified stepwise through the bi-enzymatic production of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine (GlcNAc). In this case study, sensitivity analysis is also used to evaluate the reliability of all parameters of the model suggested in literature [5], Results, from the sensitivity analysis, are used as criteria for a systematic simplification of the model structure. Consequently, model complexity was reduced without compromising the general predictive performance. A deviation of less than 5% from the original model was found.
Original languageEnglish
Title of host publication21st European Symposium on Computer Aided Process Engineering
PublisherElsevier Science
Publication date2011
Pages1346-1350
ISBN (print)978-0-444-53895-6
DOIs
StatePublished

Conference

Conference21st European Symposium on Computer Aided Process Engineering
CountryGreece
CityChalkidiki
Period29/05/1101/06/11
Internet addresshttp://www.escape-21.gr/
NameComputer Aided Chemical Engineering
Number29
ISSN (Print)1570-7946
CitationsWeb of Science® Times Cited: No match on DOI

Keywords

  • Multi-enzyme in-pot, Neu5Ac production, Mathematical model
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