Publication: Research - peer-review › Article in proceedings – Annual report year: 2011
This paper presents a methodological approach for modeling multi-enzyme in-pot processes. The methodology is exemplified stepwise through the bi-enzymatic production of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine (GlcNAc). In this case study, sensitivity analysis is also used to evaluate the reliability of all parameters of the model suggested in literature , Results, from the sensitivity analysis, are used as criteria for a systematic simplification of the model structure. Consequently, model complexity was reduced without compromising the general predictive performance. A deviation of less than 5% from the original model was found.
|Title of host publication||21st European Symposium on Computer Aided Process Engineering|
|Conference||21st European Symposium on Computer Aided Process Engineering|
|Period||29/05/11 → 01/06/11|
|Name||Computer Aided Chemical Engineering|
|Citations||Web of Science® Times Cited: No match on DOI|
- Multi-enzyme in-pot, Neu5Ac production, Mathematical model
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