Metabolism of hyperpolarized [1-(13) C]pyruvate in the isolated perfused rat lung - an ischemia study

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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  • Author: Pullinger, B

  • Author: Profka, H

  • Author: Ardenkjaer-Larsen, J H

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  • Author: Kuzma, N N

  • Author: Kadlecek, S

  • Author: Rizi, R R

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We report studies of the effect of ischemia on the metabolic activity of the intact perfused lung and its restoration after a period of reperfusion. Two groups of rat lungs were studied using hyperpolarized 1-(13) C pyruvate to compare the rate of lactate labeling differing only in the temporal ordering of ischemic and normoxic acquisitions. In both cases, a several-fold increase in lactate labeling was observed immediately after a 25-min ischemia event as was its reversal back to the baseline after 30-40 min of resumed perfusion (n = 5, p <0.025 for both comparisons). These results were corroborated by (31) P spectroscopy and correspond well to measured changes in lactate pool size determined by (1) H spectroscopy of freeze-clamped specimens. Copyright © 2012 John Wiley & Sons, Ltd.
Original languageEnglish
JournalN M R in Biomedicine
Publication date2012
Volume25
Journal number10
Pages1113-1118
ISSN0952-3480
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 4
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