TY - JOUR

T1 - Metabolic footprint of Lactobacillus acidophilus NCFM at different pH

A1 - Sulek,Karolina

A1 - Frandsen,Henrik Lauritz

A1 - Smedsgaard,Jørn

A1 - Skov,Thomas Hjort

A1 - Wilcks,Andrea

A1 - Licht,Tine Rask

AU - Sulek,Karolina

AU - Frandsen,Henrik Lauritz

AU - Smedsgaard,Jørn

AU - Skov,Thomas Hjort

AU - Wilcks,Andrea

AU - Licht,Tine Rask

PB - Springer New York LLC

PY - 2012

Y1 - 2012

N2 - Lactobacillus acidophilus NCFM is a well known microorganism from the genomic and probiotic point of view. In order to analyze the potential interactions of NCFM with the surrounding environment, in vitro tests with the metabolic footprinting approach were performed. It was found that NCFM increased the concentration of lactic acid, succinic acid, adenine and arginine in the medium. The metabolism of NCFM did not change significantly between pH 5 and 7, suggesting that other environmental factors than pH might have bigger impact on its colonization throughout the gastrointestinal tract.

AB - Lactobacillus acidophilus NCFM is a well known microorganism from the genomic and probiotic point of view. In order to analyze the potential interactions of NCFM with the surrounding environment, in vitro tests with the metabolic footprinting approach were performed. It was found that NCFM increased the concentration of lactic acid, succinic acid, adenine and arginine in the medium. The metabolism of NCFM did not change significantly between pH 5 and 7, suggesting that other environmental factors than pH might have bigger impact on its colonization throughout the gastrointestinal tract.

KW - Probiotics

KW - LCMS

KW - Lactobacillus acidophilus NCFM

KW - Metabolite footprint

KW - GIT

KW - Metabolomics

U2 - 10.1007/s11306-011-0305-4

DO - 10.1007/s11306-011-0305-4

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 2

VL - 8

SP - 244

EP - 252

ER -