Mechanistic modelling of the drying behaviour of single pharmaceutical granules
Publication: Research - peer-review › Journal article – Annual report year: 2012
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Mechanistic modelling of the drying behaviour of single pharmaceutical granules. / Thérèse F.C. Mortier, Séverine; Beer, Thomas De; Gernaey, Krist; Vercruysse, Jurgen; Fonteyne, Margot; Remon, Jean Paul; Vervaet, Chris; Nopens, Ingmar.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 80, 2012, p. 682-689.Publication: Research - peer-review › Journal article – Annual report year: 2012
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TY - JOUR
T1 - Mechanistic modelling of the drying behaviour of single pharmaceutical granules
AU - Thérèse F.C. Mortier,Séverine
AU - Beer,Thomas De
AU - Gernaey,Krist
AU - Vercruysse,Jurgen
AU - Fonteyne,Margot
AU - Remon,Jean Paul
AU - Vervaet,Chris
AU - Nopens,Ingmar
PY - 2012
Y1 - 2012
N2 - The trend to move towards continuous production processes in pharmaceutical applications enhancesthe necessity to develop mechanistic models to understand and control these processes. This workfocuses on the drying behaviour of a single wet granule before tabletting, using a six-segmented fluidisedbed drying system, which is part of a fully continuous from-powder-to-tablet manufacturing line. Thedrying model is based on a model described by Mezhericher et al. [1] and consists of two submodels.In the first drying phase (submodel 1), the surface water evaporates, while in the second drying phase(submodel 2), the water inside the granule evaporates. The second submodel contains an empirical powercoefficient, b. A sensitivity analysis was performed to study the influence of parameters on the moisturecontent of single pharmaceutical granules, which clearly points towards the importance of b on the dryingbehaviour. Experimental data with the six-segmented fluidised bed dryer were collected to calibrateb. An exponential dependence on the drying air temperature was found. Independent experiments weredone for the validation of the drying model.
AB - The trend to move towards continuous production processes in pharmaceutical applications enhancesthe necessity to develop mechanistic models to understand and control these processes. This workfocuses on the drying behaviour of a single wet granule before tabletting, using a six-segmented fluidisedbed drying system, which is part of a fully continuous from-powder-to-tablet manufacturing line. Thedrying model is based on a model described by Mezhericher et al. [1] and consists of two submodels.In the first drying phase (submodel 1), the surface water evaporates, while in the second drying phase(submodel 2), the water inside the granule evaporates. The second submodel contains an empirical powercoefficient, b. A sensitivity analysis was performed to study the influence of parameters on the moisturecontent of single pharmaceutical granules, which clearly points towards the importance of b on the dryingbehaviour. Experimental data with the six-segmented fluidised bed dryer were collected to calibrateb. An exponential dependence on the drying air temperature was found. Independent experiments weredone for the validation of the drying model.
KW - Mechanistic modelling
KW - Drying
KW - Porous material
KW - Pharmaceutical granules
KW - Model calibration
KW - Model validation
U2 - 10.1016/j.ejpb.2011.12.010
DO - 10.1016/j.ejpb.2011.12.010
M3 - Journal article
VL - 80
SP - 682
EP - 689
JO - European Journal of Pharmaceutics and Biopharmaceutics
T2 - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
ER -