Mechanistic modelling of the drying behaviour of single pharmaceutical granules

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Mechanistic modelling of the drying behaviour of single pharmaceutical granules. / Thérèse F.C. Mortier, Séverine; Beer, Thomas De; Gernaey, Krist; Vercruysse, Jurgen; Fonteyne, Margot; Remon, Jean Paul; Vervaet, Chris; Nopens, Ingmar.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 80, 2012, p. 682-689.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Thérèse F.C. Mortier, S, Beer, TD, Gernaey, K, Vercruysse, J, Fonteyne, M, Remon, JP, Vervaet, C & Nopens, I 2012, 'Mechanistic modelling of the drying behaviour of single pharmaceutical granules' European Journal of Pharmaceutics and Biopharmaceutics, vol 80, pp. 682-689., 10.1016/j.ejpb.2011.12.010

APA

Thérèse F.C. Mortier, S., Beer, T. D., Gernaey, K., Vercruysse, J., Fonteyne, M., Remon, J. P., ... Nopens, I. (2012). Mechanistic modelling of the drying behaviour of single pharmaceutical granules. European Journal of Pharmaceutics and Biopharmaceutics, 80, 682-689. 10.1016/j.ejpb.2011.12.010

CBE

Thérèse F.C. Mortier S, Beer TD, Gernaey K, Vercruysse J, Fonteyne M, Remon JP, Vervaet C, Nopens I. 2012. Mechanistic modelling of the drying behaviour of single pharmaceutical granules. European Journal of Pharmaceutics and Biopharmaceutics. 80:682-689. Available from: 10.1016/j.ejpb.2011.12.010

MLA

Vancouver

Thérèse F.C. Mortier S, Beer TD, Gernaey K, Vercruysse J, Fonteyne M, Remon JP et al. Mechanistic modelling of the drying behaviour of single pharmaceutical granules. European Journal of Pharmaceutics and Biopharmaceutics. 2012;80:682-689. Available from: 10.1016/j.ejpb.2011.12.010

Author

Thérèse F.C. Mortier, Séverine; Beer, Thomas De; Gernaey, Krist; Vercruysse, Jurgen; Fonteyne, Margot; Remon, Jean Paul; Vervaet, Chris; Nopens, Ingmar / Mechanistic modelling of the drying behaviour of single pharmaceutical granules.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 80, 2012, p. 682-689.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{65e73431154a408a813a6fc7ab019cfc,
title = "Mechanistic modelling of the drying behaviour of single pharmaceutical granules",
keywords = "Mechanistic modelling, Drying, Porous material, Pharmaceutical granules, Model calibration, Model validation",
publisher = "Elsevier BV",
author = "{Thérèse F.C. Mortier}, Séverine and Beer, {Thomas De} and Krist Gernaey and Jurgen Vercruysse and Margot Fonteyne and Remon, {Jean Paul} and Chris Vervaet and Ingmar Nopens",
year = "2012",
doi = "10.1016/j.ejpb.2011.12.010",
volume = "80",
pages = "682--689",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",

}

RIS

TY - JOUR

T1 - Mechanistic modelling of the drying behaviour of single pharmaceutical granules

A1 - Thérèse F.C. Mortier,Séverine

A1 - Beer,Thomas De

A1 - Gernaey,Krist

A1 - Vercruysse,Jurgen

A1 - Fonteyne,Margot

A1 - Remon,Jean Paul

A1 - Vervaet,Chris

A1 - Nopens,Ingmar

AU - Thérèse F.C. Mortier,Séverine

AU - Beer,Thomas De

AU - Gernaey,Krist

AU - Vercruysse,Jurgen

AU - Fonteyne,Margot

AU - Remon,Jean Paul

AU - Vervaet,Chris

AU - Nopens,Ingmar

PB - Elsevier BV

PY - 2012

Y1 - 2012

N2 - The trend to move towards continuous production processes in pharmaceutical applications enhances<br/>the necessity to develop mechanistic models to understand and control these processes. This work<br/>focuses on the drying behaviour of a single wet granule before tabletting, using a six-segmented fluidised<br/>bed drying system, which is part of a fully continuous from-powder-to-tablet manufacturing line. The<br/>drying model is based on a model described by Mezhericher et al. [1] and consists of two submodels.<br/>In the first drying phase (submodel 1), the surface water evaporates, while in the second drying phase<br/>(submodel 2), the water inside the granule evaporates. The second submodel contains an empirical power<br/>coefficient, b. A sensitivity analysis was performed to study the influence of parameters on the moisture<br/>content of single pharmaceutical granules, which clearly points towards the importance of b on the drying<br/>behaviour. Experimental data with the six-segmented fluidised bed dryer were collected to calibrate<br/>b. An exponential dependence on the drying air temperature was found. Independent experiments were<br/>done for the validation of the drying model.

AB - The trend to move towards continuous production processes in pharmaceutical applications enhances<br/>the necessity to develop mechanistic models to understand and control these processes. This work<br/>focuses on the drying behaviour of a single wet granule before tabletting, using a six-segmented fluidised<br/>bed drying system, which is part of a fully continuous from-powder-to-tablet manufacturing line. The<br/>drying model is based on a model described by Mezhericher et al. [1] and consists of two submodels.<br/>In the first drying phase (submodel 1), the surface water evaporates, while in the second drying phase<br/>(submodel 2), the water inside the granule evaporates. The second submodel contains an empirical power<br/>coefficient, b. A sensitivity analysis was performed to study the influence of parameters on the moisture<br/>content of single pharmaceutical granules, which clearly points towards the importance of b on the drying<br/>behaviour. Experimental data with the six-segmented fluidised bed dryer were collected to calibrate<br/>b. An exponential dependence on the drying air temperature was found. Independent experiments were<br/>done for the validation of the drying model.

KW - Mechanistic modelling

KW - Drying

KW - Porous material

KW - Pharmaceutical granules

KW - Model calibration

KW - Model validation

U2 - 10.1016/j.ejpb.2011.12.010

DO - 10.1016/j.ejpb.2011.12.010

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

VL - 80

SP - 682

EP - 689

ER -