• Author: Molin, M., Norway

    Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Norway

  • Author: Ydersbond, T.A., Norway

    Statistics Norway, Norway

  • Author: Ulven, S.M., Norway

    Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Norway

  • Author: Holck, M., Norway

    Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Norway

  • Author: Dahl, L., Norway

    National Institute of Nutrition and Seafood Research, Norway

  • Author: Sloth, Jens Jørgen

    Division of Food Chemistry, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860, Søborg, Denmark

  • Author: Fliegel, D., Norway

    National Institute of Nutrition and Seafood Research, Norway

  • Author: Goessler, W., Austria

    Institute for Chemistry–Analytical Chemistry, Austria

  • Author: Alexander, J., Norway

    Norwegian Institute of Public Health, Norway

  • Author: Meltzer, H.M., Norway

    Norwegian Institute of Public Health, Norway

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Blue mussels (Mytilus edulis) accumulate and biotransform arsenic (As) to a larger variety of arsenicals than most seafood. Eight volunteers ingested a test meal consisting of 150g blue mussel (680μg As), followed by 72h with an identical, low As controlled diet and full urine sampling. We provide a complete speciation, with individual patterns, of urinary As excretion. Total As (tAs) urinary excretion was 328±47μg, whereof arsenobetaine (AB) and dimethylarsinate (DMA) accounted for 66% and 21%, respectively. Fifteen minor urinary arsenicals were quantified with inductively coupled plasma mass spectrometry (ICPMS) coupled to reverse-phase, anion and cation-exchange high performance liquid chromatography (HPLC). Thio-arsenicals and non-thio minor arsenicals (including inorganic As (iAs) and methylarsonate (MA)) contributed 10% and 7% of the total sum of species excretion, respectively, but there were large individual differences in the excretion patterns. Apparently, formation of thio-arsenicals was negatively correlated to AB formation and excretion, possibly indicating a metabolic interrelationship. The results may be of toxicological relevance since DMA and MA have been classified as possibly carcinogenic, and six of the excreted As species were thio-arsenicals which recently have been recognized as toxic, while iAs toxicity is well known.
Original languageEnglish
JournalFood and Chemical Toxicology
Publication date2012
Volume50
Journal number7
Pages2462-2472
ISSN0278-6915
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 6

Keywords

  • Arsenic, Blue mussels, Thio-arsenicals, Arsenic speciation, Dietary intervention, Human
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