Locked and Unlocked Nucleosides in Functional Nucleic Acids

Publication: Research - peer-reviewJournal article – Annual report year: 2011

Not written here

Documents

DOI

  • Author: Doessing, Holger

    Univ So Denmark, Nucle Acid Ctr, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark

  • Author: Vester, Birte, Denmark

    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark

View graph of relations

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Original languageEnglish
JournalMolecules
Publication date2011
Volume16
Journal number6
Pages4511-4526
ISSN1420-3049
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 11
Download as:
Download as PDF
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBEHarvardMLAStandardVancouverShortLong
Word

Download statistics

No data available

ID: 35964876