Locked and Unlocked Nucleosides in Functional Nucleic Acids

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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  • Author: Doessing, Holger

    University of Southern Denmark

  • Author: Vester, Birte

    University of Southern Denmark, Denmark

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Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Original languageEnglish
JournalMolecules
Publication date2011
Volume16
Issue6
Pages4511-4526
ISSN1420-3049
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 14
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