TY - JOUR

T1 - Interfacial electrochemical electron transfer in biology – Towards the level of the single molecule

A1 - Zhang,Jingdong

A1 - Chi,Qijin

A1 - Hansen,Allan Glargaard

A1 - Jensen,Palle Skovhus

A1 - Salvatore,Princia

A1 - Ulstrup,Jens

AU - Zhang,Jingdong

AU - Chi,Qijin

AU - Hansen,Allan Glargaard

AU - Jensen,Palle Skovhus

AU - Salvatore,Princia

AU - Ulstrup,Jens

PB - Elsevier BV

PY - 2012

Y1 - 2012

N2 - Physical electrochemistry has undergone a remarkable evolution over the last few decades, integrating advanced techniques and theory from solid state and surface physics. Single-crystal electrode surfaces have been a core notion, opening for scanning tunnelling microscopy directly in aqueous electrolyte (in situ STM). Interfacial electrochemistry of metalloproteins is presently going through a similar transition. Electrochemical surfaces with thiol-based promoter molecular monolayers (SAMs) as biomolecular electrochemical environments and the biomolecules themselves have been mapped with unprecedented resolution, opening a new area of single-molecule bioelectrochemistry. We consider first in situ STM of small redox molecules, followed by in situ STM of thiol-based SAMs as molecular views of bioelectrochemical environments. We then address electron transfer metalloproteins, and multi-centre metalloenzymes including applied single-biomolecular perspectives based on metalloprotein/metallic nanoparticle hybrids.

AB - Physical electrochemistry has undergone a remarkable evolution over the last few decades, integrating advanced techniques and theory from solid state and surface physics. Single-crystal electrode surfaces have been a core notion, opening for scanning tunnelling microscopy directly in aqueous electrolyte (in situ STM). Interfacial electrochemistry of metalloproteins is presently going through a similar transition. Electrochemical surfaces with thiol-based promoter molecular monolayers (SAMs) as biomolecular electrochemical environments and the biomolecules themselves have been mapped with unprecedented resolution, opening a new area of single-molecule bioelectrochemistry. We consider first in situ STM of small redox molecules, followed by in situ STM of thiol-based SAMs as molecular views of bioelectrochemical environments. We then address electron transfer metalloproteins, and multi-centre metalloenzymes including applied single-biomolecular perspectives based on metalloprotein/metallic nanoparticle hybrids.

KW - Metalloproteins

KW - Single-crystal electrode surfaces

KW - Scanning tunneling microscopy

KW - Protein film voltammetry

U2 - 10.1016/j.febslet.2011.10.023

DO - 10.1016/j.febslet.2011.10.023

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

VL - 586

SP - 526

EP - 535

ER -