Interfacial electrochemical electron transfer in biology – Towards the level of the single molecule

Publication: Research - peer-reviewJournal article – Annual report year: 2011

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Physical electrochemistry has undergone a remarkable evolution over the last few decades, integrating advanced techniques and theory from solid state and surface physics. Single-crystal electrode surfaces have been a core notion, opening for scanning tunnelling microscopy directly in aqueous electrolyte (in situ STM). Interfacial electrochemistry of metalloproteins is presently going through a similar transition. Electrochemical surfaces with thiol-based promoter molecular monolayers (SAMs) as biomolecular electrochemical environments and the biomolecules themselves have been mapped with unprecedented resolution, opening a new area of single-molecule bioelectrochemistry. We consider first in situ STM of small redox molecules, followed by in situ STM of thiol-based SAMs as molecular views of bioelectrochemical environments. We then address electron transfer metalloproteins, and multi-centre metalloenzymes including applied single-biomolecular perspectives based on metalloprotein/metallic nanoparticle hybrids.
Original languageEnglish
JournalFEBS Letters
Pages (from-to)526-535
StatePublished - 2012
CitationsWeb of Science® Times Cited: 18


  • Metalloproteins, Single-crystal electrode surfaces, Scanning tunneling microscopy, Protein film voltammetry
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ID: 6322910