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Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.
Original languageEnglish
JournalCancer Letters
Publication date2010
Volume295
Journal number2
Pages191-197
ISSN0304-3835
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 5

Keywords

  • Alcohol, Gene-environment interaction, Alcohol dehydrogenase, Breast cancer, Prospective study, Population-based study
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