Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection. / Kaczkowski, Bogumil; Rossing, Maria; Andersen, Ditte; Dreher, Anita; Morevati, Marya; Visser, Melissa A.; Winther, Ole; Nielsen, Finn Cilius; Norrild, Bodil.

In: Scientific Reports, Vol. 2, 2012, p. 515.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Kaczkowski, B, Rossing, M, Andersen, D, Dreher, A, Morevati, M, Visser, MA, Winther, O, Nielsen, FC & Norrild, B 2012, 'Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection' Scientific Reports, vol 2, pp. 515., 10.1038/srep00515

APA

Kaczkowski, B., Rossing, M., Andersen, D., Dreher, A., Morevati, M., Visser, M. A., ... Norrild, B. (2012). Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection. Scientific Reports, 2, 515. 10.1038/srep00515

CBE

Kaczkowski B, Rossing M, Andersen D, Dreher A, Morevati M, Visser MA, Winther O, Nielsen FC, Norrild B. 2012. Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection. Scientific Reports. 2:515. Available from: 10.1038/srep00515

MLA

Vancouver

Kaczkowski B, Rossing M, Andersen D, Dreher A, Morevati M, Visser MA et al. Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection. Scientific Reports. 2012;2:515. Available from: 10.1038/srep00515

Author

Kaczkowski, Bogumil; Rossing, Maria; Andersen, Ditte; Dreher, Anita; Morevati, Marya; Visser, Melissa A.; Winther, Ole; Nielsen, Finn Cilius; Norrild, Bodil / Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection.

In: Scientific Reports, Vol. 2, 2012, p. 515.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{61b75547d5a04028835338ce27f3b6b6,
title = "Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection",
publisher = "Nature Publishing Group",
author = "Bogumil Kaczkowski and Maria Rossing and Ditte Andersen and Anita Dreher and Marya Morevati and Visser, {Melissa A.} and Ole Winther and Nielsen, {Finn Cilius} and Bodil Norrild",
year = "2012",
doi = "10.1038/srep00515",
volume = "2",
pages = "515",
journal = "Scientific Reports",
issn = "2045-2322",

}

RIS

TY - JOUR

T1 - Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection

A1 - Kaczkowski,Bogumil

A1 - Rossing,Maria

A1 - Andersen,Ditte

A1 - Dreher,Anita

A1 - Morevati,Marya

A1 - Visser,Melissa A.

A1 - Winther,Ole

A1 - Nielsen,Finn Cilius

A1 - Norrild,Bodil

AU - Kaczkowski,Bogumil

AU - Rossing,Maria

AU - Andersen,Ditte

AU - Dreher,Anita

AU - Morevati,Marya

AU - Visser,Melissa A.

AU - Winther,Ole

AU - Nielsen,Finn Cilius

AU - Norrild,Bodil

PB - Nature Publishing Group

PY - 2012

Y1 - 2012

N2 - The interaction between human papillomavirus (HPV) and host cells is not well understood. We investigate the early stage of HPV infections by global expression profiling in a cell model, in which HaCaT cells were transfected with HPV11, HPV16 or HPV45 genomes. We report the differential expression of genes not previously implicated in HPV biology, such as the PSG family and ANKRD1, and of genes implicated in the biology of other viruses, e. g. MX1, IFI44 and DDX60. Carcinogenesis-related genes, e. g. ABL2, MGLL and CYR61, were upregulated by high-risk HPV16 and -45. The integrative analysis revealed the suppression of DNA repair by HPV11 and -16, and downregulation of cytoskeleton genes by all HPV types. Various signalling pathways were affected by the HPVs: IL-2 by HPV11; JAK-STAT by HPV16; and TGF-beta, NOTCH and tyrosine kinase signalling by HPV45. This study uncovered novel strategies employed by HPV to establish infection and promote uncontrolled growth.

AB - The interaction between human papillomavirus (HPV) and host cells is not well understood. We investigate the early stage of HPV infections by global expression profiling in a cell model, in which HaCaT cells were transfected with HPV11, HPV16 or HPV45 genomes. We report the differential expression of genes not previously implicated in HPV biology, such as the PSG family and ANKRD1, and of genes implicated in the biology of other viruses, e. g. MX1, IFI44 and DDX60. Carcinogenesis-related genes, e. g. ABL2, MGLL and CYR61, were upregulated by high-risk HPV16 and -45. The integrative analysis revealed the suppression of DNA repair by HPV11 and -16, and downregulation of cytoskeleton genes by all HPV types. Various signalling pathways were affected by the HPVs: IL-2 by HPV11; JAK-STAT by HPV16; and TGF-beta, NOTCH and tyrosine kinase signalling by HPV45. This study uncovered novel strategies employed by HPV to establish infection and promote uncontrolled growth.

UR - http://www.nature.com/srep/2012/120717/srep00515/full/srep00515.html

U2 - 10.1038/srep00515

DO - 10.1038/srep00515

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

VL - 2

SP - 515

ER -