Integrative analyses reveal novel strategies in HPV11,-16 and-45 early infection

Publication: Research - peer-reviewJournal article – Annual report year: 2012

  • Author: Kaczkowski, Bogumil

    University of Copenhagen, Denmark

  • Author: Rossing, Maria

    Copenhagen University Hospital, Denmark

  • Author: Andersen, Ditte

    University of Copenhagen, Denmark

  • Author: Dreher, Anita

    University of Copenhagen, Denmark

  • Author: Morevati, Marya

    University of Copenhagen, Denmark

  • Author: Visser, Melissa A.

    University of Copenhagen, Denmark

  • Author: Winther, Ole

    Cognitive Systems, Department of Informatics and Mathematical Modeling, Technical University of Denmark, Richard Petersens Plads, 2800, Lyngby, Denmark

  • Author: Nielsen, Finn Cilius

    Copenhagen University Hospital, Denmark

  • Author: Norrild, Bodil

    University of Copenhagen, Denmark

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The interaction between human papillomavirus (HPV) and host cells is not well understood. We investigate the early stage of HPV infections by global expression profiling in a cell model, in which HaCaT cells were transfected with HPV11, HPV16 or HPV45 genomes. We report the differential expression of genes not previously implicated in HPV biology, such as the PSG family and ANKRD1, and of genes implicated in the biology of other viruses, e. g. MX1, IFI44 and DDX60. Carcinogenesis-related genes, e. g. ABL2, MGLL and CYR61, were upregulated by high-risk HPV16 and -45. The integrative analysis revealed the suppression of DNA repair by HPV11 and -16, and downregulation of cytoskeleton genes by all HPV types. Various signalling pathways were affected by the HPVs: IL-2 by HPV11; JAK-STAT by HPV16; and TGF-beta, NOTCH and tyrosine kinase signalling by HPV45. This study uncovered novel strategies employed by HPV to establish infection and promote uncontrolled growth.
Original languageEnglish
JournalScientific Reports
Publication date2012
Volume2
Pages515
ISSN2045-2322
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 4
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