Individual Differences in the Alignment of Structural and Functional Markers of the V5/MT Complex in Primates

Research output: Research - peer-reviewJournal article – Annual report year: 2016

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  • Author: Large, S.I.

    University of Oxford, United Kingdom

  • Author: Bridge, H.

    University of Oxford, United Kingdom

  • Author: Ahmed, Be-Nazir

    University of Oxford, United Kingdom

  • Author: Clare, S.

    University of Oxford, United Kingdom

  • Author: Kolasinski, J.

    University of Oxford, United Kingdom

  • Author: Lam, K. W F

    University of Oxford, United Kingdom

  • Author: Miller, K. L.

    University of Oxford, United Kingdom

  • Author: Dyrby, Tim Bjørn

    Image Analysis & Computer Graphics, Department of Applied Mathematics and Computer Science , Technical University of Denmark, Richard Petersens Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Parker, A. J.

    University of Oxford, United Kingdom

  • Author: Smith, J. E. T.

    University of Oxford, United Kingdom

  • Author: Daubney, G.

    University of Oxford, United Kingdom

  • Author: Sallet, J.

    University of Oxford, United Kingdom

  • Author: Bell, A. H.

    University of Oxford, United Kingdom

  • Author: Krug, K.

    University of Oxford, United Kingdom

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Extrastriate visual area V5/MT in primates is defined both structurally by myeloarchitecture and functionally by distinct responses to visual motion. Myelination is directly identifiable from postmortem histology but also indirectly by image contrast with structural magnetic resonance imaging (sMRI). First, we compared the identification of V5/MT using both sMRI and histology in Rhesus macaques. A section-by-section comparison of histological slices with in vivo and postmortem sMRI for the same block of cortical tissue showed precise correspondence in localizing heavy myelination for V5/MT and neighboring MST. Thus, sMRI in macaques accurately locates histologically defined myelin within areas known to be motion selective. Second, we investigated the functionally homologous human motion complex (hMT+) using high-resolution in vivo imaging. Humans showed considerable intersubject variability in hMT+ location, when defined with myelin-weighted sMRI signals to reveal structure. When comparing sMRI markers to functional MRI in response to moving stimuli, a region of high myelin signal was generally located within the hMT+ complex. However, there were considerable differences in the alignment of structural and functional markers between individuals. Our results suggest that variation in area identification for hMT+ based on structural and functional markers reflects individual differences in human regional brain architecture.
Original languageEnglish
JournalCerebral Cortex
Volume26
Issue number10
Pages (from-to)3928-3944
ISSN1047-3211
DOIs
StatePublished - 2016

Bibliographical note

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/),
which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

CitationsWeb of Science® Times Cited: 6

    Research areas

  • Histology, Monkey, MRI, Myelination, Visual cortex
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